NCOG-36. DOSIMETRY AND COGNITIVE FUNCTION AFTER RADIATION THERAPY IN LOW GRADE GLIOMAS

Wafa Asha; Sami Koro; Wei Wei; Yanwen Chen; Eric Murray; Erin Murphy; John Suh; Samuel Chao; Lilyana Angelov; David Peereboom

doi:10.1093/neuonc/noac209.787

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NCOG-36. DOSIMETRY AND COGNITIVE FUNCTION AFTER RADIATION THERAPY IN LOW GRADE GLIOMAS

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NCOG-36. DOSIMETRY AND COGNITIVE FUNCTION AFTER RADIATION THERAPY IN LOW GRADE GLIOMAS

Wafa Asha, Sami Koro, Wei Wei, Yanwen Chen, Eric Murray, Erin Murphy, John Suh, Samuel Chao, Lilyana Angelov and David Peereboom

Neuro-oncology (Charlottesville, Va.), Vol.24(Suppl 7), pp.vii205-vii205

11/14/2022

DOI: 10.1093/neuonc/noac209.787

PMCID: PMC9660644

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Abstract

PURPOSE We found that cognitive function remained stable following radiotherapy with concurrent and adjuvant temozolomide (RT+TMZ) in low-grade glioma (LGG) patients evaluated prospectively up to 2 years. This study evaluates the effects of radiotherapy dosimetry on neurocognitive function in a larger group of molecularly defined LGG patients treated with radiotherapy (RT). METHODS A total of 39 LGG patients were evaluated with comprehensive psychometric tests at baseline (prior to RT) and at various time intervals following RT. Patients served as their own controls by evaluating change in scores over time. Dosimetric parameters included mean and maximum dose to the pituitary, mean and maximum dose to the hypothalamus, mean dose to contralateral hippocampus, brain, cochlea, and PTV volume. Correlation between dosimetry and neurocognitive tests were assessed by Spearman correlation for the baseline correlation and Cox proportional hazard regression analysis for the survival analysis. RESULTS Patients were followed for a median of 60 months. Overall, patients showed group mean test scores similar to their initial performances following radiotherapy on all psychometric measures. There was a significant correlation between mean dose to cochlea (p=0.006), pituitary (p=0.035), mean PTV volume (0.019) and neurocognitive outcome.. CONCLUSION Cognitive function remained stable following radiotherapy in LGG patients evaluated prospectivelys. There was a significant correlation between specific dosimetric endpoints and neurocognitive outcomes over time. Further study needs to be done in a larger population to validate these findings.

Outcome Measures and Neuro-Cognitive Outcomes

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Title: Subtitle: NCOG-36. DOSIMETRY AND COGNITIVE FUNCTION AFTER RADIATION THERAPY IN LOW GRADE GLIOMAS
Creators: Wafa Asha - Cleveland Clinic
Sami Koro - Cleveland Clinic
Wei Wei - Cleveland Clinic
Yanwen Chen - Cleveland Clinic
Eric Murray - Cleveland Clinic
Erin Murphy - Cleveland Clinic
John Suh - Cleveland Clinic
Samuel Chao - Cleveland Clinic
Lilyana Angelov - Cleveland Clinic
David Peereboom - Cleveland Clinic
Resource Type: Abstract
Publication Details: Neuro-oncology (Charlottesville, Va.), Vol.24(Suppl 7), pp.vii205-vii205
DOI: 10.1093/neuonc/noac209.787
PMCID: PMC9660644
ISSN: 1522-8517
eISSN: 1523-5866
Publisher: Oxford University Press
Language: English
Date published: 11/14/2022
Academic Unit: Radiation Oncology
Record Identifier: 9984700254702771

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