Abstract
NCOG-45. A prospective study integrating neuroimaging, neuro-cognitive function, patient-reported outcomes in IDH-mutant gliomas: preliminary results
Neuro-oncology (Charlottesville, Va.), Vol.27(Supplement_5), pp.v332-v332
11/11/2025
DOI: 10.1093/neuonc/noaf201.1312
PMCID: PMC12601365
Abstract
INTRO
Isocitrate dehydrogenase mutant (IDH-mt) gliomas are incurable brain tumors primarily affecting young adults. Developing novel surrogate endpoints of disease progression requires understanding the relationships between tumor growth, patient function, and quality of life (QOL). In this prospective study, we report preliminary analyses describing neurocognitive function (NCF) and QOL with brain connectivity.
METHODS
Patients’ standardized (M = 50, SD = 10) NIH Toolbox and PROMIS measures were collected as well as Area Deprivation Index (ADI). We used exact Wilcoxon tests and Spearman correlations for comparisons.
RESULTS
We accrued 27 patients with a mean age of 36.6±9.1 years. Most identified as female (59.3%). The average national ADI rank was 43±17 and state ADI decile was 3±2. About half had a gross total resection (51.9%). Tumors were mostly grade II (44.4%) or grade III (48.2%); two individuals (7.4%) had a grade IV tumor. Most patients reported high (t >= 50) levels of anxiety (74.1%), fatigue (63.0%), and sadness (63.0%), and most scored below average (t < 50) on a measure of executive function (74.1%). Conversely, they showed high (t >= 50) ability on measures of episodic memory (77.8%) and visual-spatial memory (70.4%). Female patients performed better on the Oral Symbol Digit test (Mdn = 54.0 vs 41.0; p =.01). Patients with a gross total resection reported higher levels of fatigue (Mdn = 58.3 vs 49.2; p =.003) and depression (Mdn = 58.8 vs 46.8; p =.02) as well as low social participation (Mdn = 44.8 vs 58.0; p =.002). Finally, patients living in more adverse areas reported lower inter-network connectivity (s = -0.56; p =.01).
DISCUSSION
Preliminary analyses of our prospective study demonstrate that NCF and QOL is impaired in patients with IDH-mt glioma. Further integration of neuroimaging with patient function will advance treatment approaches.
Details
- Title: Subtitle
- NCOG-45. A prospective study integrating neuroimaging, neuro-cognitive function, patient-reported outcomes in IDH-mutant gliomas: preliminary results
- Creators
- William Adams - Loyola University ChicagoKrithi GopinathCarolina Pusec - University of Wisconsin–MadisonAzam Ahmed - University of Wisconsin–MadisonMustafa Baskaya - University of Wisconsin–MadisonDallas MillerScott VandenbergLaura LawrenceJon A Wieser - University of Wisconsin–MadisonAlexander B Remsik - University of Wisconsin–MadisonAryeh Blumenreich - University of Wisconsin–MadisonAshley Parr - University of Wisconsin–MadisonMichael C Veronesi - University of Wisconsin–MadisonAlan LozierMichelle MackayPallavi Tiwari - University of Wisconsin–MadisonVeena Nair - University of Wisconsin–MadisonBrett Morris - University of Wisconsin–MadisonVivek Prabhakaran - University of Wisconsin–MadisonAnkush Bhatia - University of Wisconsin–MadisonJane S Paulsen - University of Wisconsin–Madison
- Resource Type
- Abstract
- Publication Details
- Neuro-oncology (Charlottesville, Va.), Vol.27(Supplement_5), pp.v332-v332
- DOI
- 10.1093/neuonc/noaf201.1312
- PMCID
- PMC12601365
- ISSN
- 1522-8517
- eISSN
- 1523-5866
- Publisher
- OXFORD UNIV PRESS INC
- Language
- English
- Date published
- 11/11/2025
- Academic Unit
- Psychiatry
- Record Identifier
- 9985027353102771
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