Abstract
Neuroprogramming of prenatal phthalate exposures on fluid cognition: A latent variable modeling approach to quantify exposure burden and integrate neurobehavioral data
Neurotoxicology and teratology, Vol.109(Supplement 1), 107495
05/2025
DOI: 10.1016/j.ntt.2025.107495
Abstract
Background
Phthalates are endocrine-disrupting chemicals with neuroactive properties linked to maladaptive neurodevelopment in children. However, few studies have utilized latent variable methodologies to estimate their cumulative impact and assess the complex integration of cognitive processes that characterize fluid cognition.
Objective
We investigated the prenatal trimester-specific neuroprogramming effects of the phthalate burden scores on children's fluid cognition.
Methods
Children (n = 626) aged 6–9 years from a prospective pregnancy cohort in Mexico City were administered the CANTAB, completing the between error, strategy, and mean latency measures representative of fluid cognition. Phthalate metabolites were measured in maternal urine collected at 2nd and 3rd trimesters. A CFA validated and quantified two correlated latent phthalate burden scores representing prenatal exposure to low molecular weight (LMW) and high molecular weight (HMW) phthalates. Trimester-specific models using a covariate-adjusted SEM estimated the neuroprogramming of latent phthalate burden scores on a latent construct of fluid cognition, an integration of working memory, executive function, and attention tasks.
Results
In the 3rd trimester, higher LMW phthalate burden was associated with poorer fluid cognition (b = −0.76; [95 %CI:-1.46,-0.06]; p = 0.03), while HMW phthalate burden showed a positive effect (b = 0.82; [95 %CI:0.05,1.58]; p = 0.04). Conversely, in the 2nd trimester, neither burden levels of LMW (b = −0.22; [95 %CI:-0.71,0.28]; p = 0.39) nor HMW (b = 0.21; [95 %CI:-0.33,0.75]; p = 0.44) phthalate demonstrated significant associations with fluid cognitive performance.
Conclusion
The temporal sensitivity of prenatal phthalate exposures on fluid cognition showed effects in later stages, with higher LMW burden linked to poorer performance and HMW burden showing a positive association.
Details
- Title: Subtitle
- Neuroprogramming of prenatal phthalate exposures on fluid cognition: A latent variable modeling approach to quantify exposure burden and integrate neurobehavioral data
- Creators
- Jamil M. Lane - Icahn School of Medicine at Mount SinaiNathan Cohen - Icahn School of Medicine at Mount SinaiVishal Midya - Icahn School of Medicine at Mount SinaiCecilia S. Alcala - Icahn School of Medicine at Mount SinaiShoshannah Eggers - University of IowaJordan Leader - Icahn School of Medicine at Mount SinaiMariana Torres-Calapiz - National Institute of Perinatology, Mexico City, MexicoYoussef Oulhote - Icahn School of Medicine at Mount SinaiDamaskini Valvi - Icahn School of Medicine at Mount SinaiMartha Tellez-Rojo - National Institute of Public Health, Morelos, MexicoRobert O. Wright - Icahn School of Medicine at Mount SinaiShelley H. Liu - Icahn School of Medicine at Mount Sinai
- Resource Type
- Abstract
- Publication Details
- Neurotoxicology and teratology, Vol.109(Supplement 1), 107495
- DOI
- 10.1016/j.ntt.2025.107495
- ISSN
- 0892-0362
- eISSN
- 1872-9738
- Publisher
- Elsevier Inc; OXFORD
- Language
- English
- Date published
- 05/2025
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984833486002771
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