Abstract
Nitric oxide but not prostaglandins is obligatory to the blood flow response during recovery following forearm exercise in humans
The FASEB journal, Vol.25(S1), pp.1108.11-1108.11
04/2011
DOI: 10.1096/fasebj.25.1_supplement.1108.11
Abstract
We tested the hypothesis that inhibition of prostaglandins and nitric oxide (NO) would have an additive effect on recovery of blood flow following rhythmic forearm exercise in 15 male subjects (26 ± 2 years). In separate protocols subjects performed forearm exercise (20% of maximum) for nine minutes. Forearm blood flow (FBF; ultrasound) and brachial artery pressure were measured at baseline, during exercise, and recovery. In protocol 1 (n = 7), exercise was repeated during cyclooxygenase (COX) inhibition (Ketorolac) alone and during Ketorolac/NOS inhibition (NG‐monomethyl‐L‐arginine; L‐NMMA). In protocol 2 (n = 8), exercise was repeated during L‐NMMA alone and during L‐NMMA/Ketorolac. Total FBF was calculated as the area under the curve over three minutes following exercise (recovery). Protocol 1: Recovery flow was not reduced by COX inhibition compared to control (468 ± 78 vs. 527 ± 74 ml; P = 0.18), but substantially attenuated during combined COX/NOS inhibition (290 ± 42; P < 0.01 vs. Ketorolac alone). Protocol 2: Recovery flow was attenuated with NOS inhibition alone compared to control (571 ± 165 vs. 829 ± 180 ml; P≤0.01), but not attenuated further during combined NOS/COX inhibition (540 ± 133 ml; P = 0.27 vs. L‐NMMA alone). These data indicate that NO but not prostaglandins contribute to blood flow recovery post forearm exercise.
NIH HL‐46493 (MJJ), AR‐55819 (DPC) and by CTSA RR‐024150
Details
- Title: Subtitle
- Nitric oxide but not prostaglandins is obligatory to the blood flow response during recovery following forearm exercise in humans
- Creators
- John Roger Alden ShepherdBranton G. Walker - Mayo ClinicMichael J. Joyner - Mayo ClinicDarren P. Casey - Mayo Clinic in Florida
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.25(S1), pp.1108.11-1108.11
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.25.1_supplement.1108.11
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984294928402771
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