Abstract
Novel mouse model of MCMV-induced adaptive NK cells
The Journal of immunology (1950), Vol.208(1_Supplement), pp.126-126.07
05/01/2022
DOI: 10.4049/jimmunol.208.Supp.126.07
Abstract
Abstract NK cells are important mediators of viral control with the capacity to form adaptive immune features following infection. However, studies of infection-induced adaptive NK cells require adoptive cell transfer to lower the precursor frequency of ‘antigen-specific’ NK cells, potentially limiting the diversity of the NK cell response. In seeking an unmanipulated model to probe the adaptive NK cells, we interrogated a wide range of Collaborative Cross (CC) inbred mice, inbred mouse strains which exhibit broad genetic diversity across strains. Our assessment identified and validated a putative ‘ideal’ CC strain, CC006, which does not require manipulation to generate and maintain adaptive NK cells. Critically, CC006 mice, in contrast to C57Bl/6 mice, are capable of developing enhanced NK cell-mediated protective responses to MCMV infection following m157-mediated vaccination. This work both furthers our understanding of adaptive NK cells and demonstrates the utility of CC mice in the development and interrogation of immunologic models. Supported by T32AI007511 (IJJ), T32AI007485 (IJJ), 5R01AI114543 (VPB), 1R35GM134880 (VPB), U01-AI150680 (DLF)
Details
- Title: Subtitle
- Novel mouse model of MCMV-induced adaptive NK cells
- Creators
- Isaac J JensenMatthew D MartinSandeep K TripathyVladimir P BadovinacDonna L Farber
- Resource Type
- Abstract
- Publication Details
- The Journal of immunology (1950), Vol.208(1_Supplement), pp.126-126.07
- DOI
- 10.4049/jimmunol.208.Supp.126.07
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English
- Date published
- 05/01/2022
- Academic Unit
- Pathology
- Record Identifier
- 9984355058302771
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