Abstract
Outcomes by tobacco history in E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group
Journal of clinical oncology, Vol.40(16_suppl), pp.6077-6077
06/01/2022
DOI: 10.1200/JCO.2022.40.16_suppl.6077
Abstract
6077 Background: E3311 is a phase II randomized study which showed favorable outcomes among intermediate (INT) risk HPV+ OPC patients (pts) who underwent TOS followed by pathology-guided or adapted, deintensified adjuvant treatment. Among HPV+ pts treated with definitive chemoradiation, survival outcomes are worse among those who smoked > 10 pack years (pk-yrs). Methods: We retrospectively analyzed demographics, pathologic results, and efficacy outcomes from E3311 by smoking group (current (C) vs. former (F) and > 10 vs. ≤10 pk-yrs – the latter a pre-specified stratification factor for INT patients). Binary and categorical variables were compared using a chi-square test (or Fisher’s exact test for small sample sizes). Ordinal variables were compared using a Wilcoxon rank sum test. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method and compared using a log-rank test. Results: Among 359 evaluable pts, performance status (PS) was significantly worse for pts with > 10 pk-yrs vs. ≤10 pk-yrs (15.4% vs. 7.9% with PS of 1, p = 0.034). Primary site, margin status, histologic grade, stage, and extranodal extension were not significantly different between the groups of > 10 vs. ≤10 pk-yrs. Smoking status (F vs. C) was available for 182 pts with a history of smoking. Slightly more C vs. F smokers had tonsil as primary site (79.5% vs. 65.0%, p = 0.09). Positive margins were significantly more frequent among C smokers (10.3% vs. 2.1%; p = 0.029). Overall, there were no significant differences in PFS (p = 0.55) or OS (p = 0.94), comparing those with > 10 vs. ≤10 pk-yrs, or comparing C vs. F smokers (p = 0.76, p = 0.82, respectively). Similarly, no significant differences were observed within the treatment arms. (Table 1) Conclusions: In this analysis of smoking status in E3311, INT risk HPV+ OPC pts who are C smokers or have a history of > 10 pk-yrs had favorable 3-yr PFS and OS rates that were not significantly worse than those with < 10 pk-yrs history. This data represents the first treatment approach for HPV+ OPC in which outcomes were not influenced by smoking status. Clinical trial information: NCT01898494. [Table: see text]
Details
- Title: Subtitle
- Outcomes by tobacco history in E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group
- Creators
- Ranee Mehra - University of Maryland, BaltimoreYael Flamand - Dana-Farber Cancer InstituteHarry Quon - Johns Hopkins UniversityJoaquin J. Garcia - Mayo ClinicGregory S. Weinstein - University of PennsylvaniaUmamaheswar Duvvuri - University of PittsburghBert W. O'Malley - University of Maryland, BaltimoreEnver Ozer - The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteGiovana R. Thomas - University of MiamiWayne Koch - Johns Hopkins MedicineNeil D. Gross - The University of Texas MD Anderson Cancer CenterRichard Bryan Bell - Providence Portland Medical CenterNabil F. Saba - Emory UniversityMiriam Lango - The University of Texas MD Anderson Cancer CenterRodrigo Bayon - University of IowaBarbara Burtness - Yale Cancer CenterRobert L. Ferris - University of Pittsburgh Medical Center
- Resource Type
- Abstract
- Publication Details
- Journal of clinical oncology, Vol.40(16_suppl), pp.6077-6077
- DOI
- 10.1200/JCO.2022.40.16_suppl.6077
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Grant note
- DOI: 10.13039/100000002, name: U.S. National Institutes of Health.
- Language
- English
- Date published
- 06/01/2022
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984339315302771
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