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P081/218  Morphomechanical analysis of intracranial aneurysms
Abstract   Open access   Peer reviewed

P081/218  Morphomechanical analysis of intracranial aneurysms

Jacob Miller, Sebastian Sanchez, Adam Galloy, Marco Nino, Katherine Guijarro-Falcon, Andres Gudino, David Hasan and Edgar Samaniego
Journal of neurointerventional surgery, Vol.15(Suppl 2), pp.A48-A48
09/01/2023
DOI: 10.1136/jnis-2023-ESMINT.114
url
https://doi.org/10.1136/jnis-2023-ESMINT.114View
Published (Version of record) Open Access

Abstract

Introduction It is unknown why aneurysm rupture occurs at a specific location in the aneurysm wall. Aim of Study Perform a comprehensive analysis of brain aneurysms. This includes aneurysmal wall enhancement (AWE), computational fluid dynamics (CFD) and finite element analysis (FEA) of different areas of the aneurysm. Methods Forty-seven unruptured saccular aneurysm were included in the study. 3T high resolution vessel wall imaging was performed. 3D Segmentations of the aneurysms were generated with 3D Slicer to assess: AWE using post-contrast signal intensity (SI) heatmaps; Wall Tension (WT) calculated from FEA; time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and wall shear stress gradient (WSSG) from CFD. A detailed compartmental analysis was performed. Results Eighteen aneurysms were irregular and eleven had blebs. WT, TAWSS, and WSSG were higher in the neck compared to the dome (p<0.001, p=0.02 and p<0.001, respectively). Conversely, AWE and OSI were higher in the dome compared to the neck (p=0.01 and p=0.03, respectively). In aneurysms with blebs, WT, WSSG, and AWE were significantly different between the bleb, neck, and aneurysm body (p<0.001, p=0.04 and p=0.03, respectively). Blebs had the highest AWE in the aneurysm. However, the lowest points of WT and WSSG in the aneurysms were in the bleb. Conclusion A comprehensive morphomechanical assessment may identify high risk areas of rupture within the aneurysm. Unstable areas, such as blebs, had a high AWE and low WSSG and WT. The morphomechanical features also differed in the aneurysm neck compared to the body. Disclosure of Interest Nothing to disclose
 Aneurysms Shear stress

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