Abstract
P2-260 Population-based prevalence of Duchenne/Becker muscular dystrophy (DBMD) in the USA
Journal of Epidemiology and Community Health, Vol.65(Suppl 1), pp.A293-A294
08/2011
DOI: 10.1136/jech.2011.142976j.93
Abstract
Introduction DBMD has an estimated prevalence of 1/3500 male births. Worldwide, this estimate varies, likely due to differences in diagnostic criteria, ascertainment, and survival. To date, no U.S. population-based DBMD prevalence data by race/ethnicity have been published.MethodsIn 2002, the Centers for Disease Control and Prevention established the MD STARnet to conduct population-based DBMD surveillance in four U.S. sites. Each site conducts active surveillance to identify males with DBMD born since January 1982. Using these data, we calculated DBMD prevalence by race/ethnic subgroups and birth intervals (1986–1990; 1991–1995; 1996–2000). Prevalence was calculated as: [number of DBMD males age 5–9 years/number of male residents, age 5–9 years]. With the average age at DBMD diagnosis about 5 years, census data used to identify male residents per birth interval were those published for the following interval (eg, 2005 estimates used for 1996–2000 births).ResultsFrom 1986 to 2000, 321 DBMD males resided in an MD STARnet site during one or more birth intervals, which produced a prevalence of 1/5000 residents. Race/ethnic-specific prevalence tended to be higher for Hispanics than non-Hispanic whites or African-Americans. Prevalence tended to be decreased for the most recent birth interval.ConclusionOur results are the first U.S. population-based report of race/ethnic-specific DBMD prevalence. Expansion of MD STARnet to two additional sites will permit computing prevalence for additional race/ethnic subgroups and birth intervals.
Details
- Title: Subtitle
- P2-260 Population-based prevalence of Duchenne/Becker muscular dystrophy (DBMD) in the USA
- Creators
- P Romitti - The University of Iowa, Iowa City, Iowa, USAS Puzhankara - The University of Iowa, Iowa City, Iowa, USAG Zamba - The University of Iowa, Iowa City, Iowa, USAS Nabukera - The University of Iowa, Iowa City, Iowa, USAK James - University of Colorado, Denver, Colorado, USAJ Andrews - University of Arizona, Tucson, Arizona, USAD Fox - New York State Department of Health, Troy, New York, USAC Cunniff - University of Arizona, Tucson, Arizona, USAE Ciafaloni - University of Rochester, Rochester, New York, USAC Druschel - New York State Department of Health, Troy, New York, USAK Mathews - The University of Iowa, Iowa City, Iowa, USAD Matthews - University of Colorado, Denver, Colorado, USAL Miller - Colorado Department of Public Health and EnvironmentS Pandya - University of Rochester, Rochester, New York, USAS Au - Hawaii Department of Health, Honolulu, Hawaii, USAS Scollon - Hawaii Department of Health, Honolulu, Hawaii, USAM Adams - Centers for Disease Control and Prevention, Atlanta, Georgia, USAN Street - Centers for Disease Control and Preventionthe Muscular Dystrophy Surveillance, Tracking, Research Network (MD STARnet)
- Resource Type
- Abstract
- Publication Details
- Journal of Epidemiology and Community Health, Vol.65(Suppl 1), pp.A293-A294
- DOI
- 10.1136/jech.2011.142976j.93
- ISSN
- 0143-005X
- eISSN
- 1470-2738
- Language
- English
- Date published
- 08/2011
- Academic Unit
- Biostatistics; Epidemiology; Radiology; Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9983995106802771
Metrics
10 Record Views