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PE-534542-005 VIGOROUS EXERCISE IS ASSOCIATED WITH BETTER QUALITY OF LIFE IN PEDIATRIC PATIENTS WITH LONG QT SYNDROME: DATA FROM THE PROSPECTIVE, MULTINATIONAL LIFESTYLE AND EXERCISE IN LQTS (LIVE-LQTS) STUDY
Abstract   Peer reviewed

PE-534542-005 VIGOROUS EXERCISE IS ASSOCIATED WITH BETTER QUALITY OF LIFE IN PEDIATRIC PATIENTS WITH LONG QT SYNDROME: DATA FROM THE PROSPECTIVE, MULTINATIONAL LIFESTYLE AND EXERCISE IN LQTS (LIVE-LQTS) STUDY

Michael J. Ackerman, Rachel Lampert, Amy Cassedy, Sharlene Day, Dominic J. Abrams, Barbara Ainsworth, Peter F. Aziz, Seshadri Balaji, Charles I. Berul, Johan M. Bos, …
Heart rhythm, Vol.23(4 Supplement), pp.S40-S40
04/2026
DOI: 10.1016/j.hrthm.2026.03.088

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Abstract

Background The impact of exercise on quality of life (QOL) in pediatric patients with long QT syndrome (LQTS) has not been described. Objective This study tested if QOL was higher in pediatric LQTS patients who vigorously exercised compared to those exercising non-vigorously. Methods LQTS patients 8-17 yrs old were enrolled at 30 sites from 2015-2022. LQTS patients and parent-proxies reported QOL scores at baseline using the Pediatric Cardiac Quality of Life Inventory (PCQLI) [Total, Disease Impact, and Psychosocial Impact] and the Pediatric Quality of Life Inventory (PedsQL) [Total, Physical Health, and Psychosocial Summary]. Exercise intensity was defined as vigorous [≥6 Metabolic Equivalent Task for > 2 months/year] or non-vigorous. Covariates included demographic and clinical variables. General Linear Models was used to construct models and effect size associations were reported [Partial Eta2]. Results Among 483 pediatric LQTS patients, 297 exercised vigorously and 186 non-vigorously (female=51%, age 13±3 years). Vigorous exercise was associated with significantly higher patient- and parent-proxy reported PCQLI Total, Disease Impact and Psychosocial Impact and PedsQL Total, Physical, and Psychosocial domains. (Table). Clinical factors were also significantly associated with both patient- and parent-proxy reported PCQLI domains. On the PedsQL, however, while clinical factors were associated with parent-proxy reported QOL, for children only vigorous exercise (and demographics) predicted QOL. Conclusion Among children with LQTS, vigorous exercisers and their parent-proxies reported better physical and psychosocial QOL. These data should inform shared decision-making among providers, parents, and LQTS pediatric patients considering vigorous exercise.

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