Abstract
PO-01-156 UNVEILING CLINICAL AND IMAGING PREDICTORS OF VENTRICULAR TACHYCARDIA ABLATION OUTCOMES IN STRUCTURAL HEART DISEASE PATIENTS: INSIGHTS FROM MULTIVARIATE ANALYSIS OF 508 PROCEDURES
Heart rhythm, Vol.21(5 Suppl), pp.S155-S155
05/2024
DOI: 10.1016/j.hrthm.2024.03.567
Abstract
Background
Multiple risk factors for arrhythmia recurrence after Ventricular Tachycardia (VT) ablation have been identified. However, the cumulative impact of these risk factors has not been evaluated, making it challenging to predict these risks in patients with multiple coexisting conditions.
Objective
The goal of the study was to pinpoint particular risk categories for VT recurrence, repeat VT ablation, and arrhythmic death.
Methods
We retrospectively collected variables from all continuous ablation procedures and patient demographics and analyzed these variables using a Cox proportional hazard model. Comorbidities included in the multivariate model were those that were significant (p< 0.05) on univariate regression and/or were clinically relevant. Primary outcomes included arrhythmic death, repeat ablation, and VT recurrence indicated by ICD therapy after 3 months following ablation.
Results
A total of 508 consecutive ablations between 2012 and 2022 for 399 patients (329 males, aged 60.9, sd:15.1 years) were used for our analysis, with a median (IQR) followup of 702 (228, 1482) days. Fifteen comorbidities and five laboratory or imaging test variables were selected to predict the primary outcome using univariate analysis. Older age and male sex were significant predictors only on univariate analysis, whereas CHF [aHR= 1.36 (1.01-1.82)], non-ischemic cardiomyopathy (NICM) [aHR= 2.13 (1.64-2.77)], atrial arrhythmias [aHR= 1.51 (1.17-1.95)], and CKD [aHR= 1.71 (1.31-2.24)] were significant predictors even on multivariate analysis.
Conclusion
Several factors are responsible for increasing the risk of recurrent VT post-ablation. Based on our study population, NICM, atrial arrhythmias, and CKD appear to be independent clinical risk factors when other comorbidities and imaging findings are accounted for. These data are in keeping with the findings of national databases. The role of atrial arrhythmias in begetting VT needs further study.
Details
- Title: Subtitle
- PO-01-156 UNVEILING CLINICAL AND IMAGING PREDICTORS OF VENTRICULAR TACHYCARDIA ABLATION OUTCOMES IN STRUCTURAL HEART DISEASE PATIENTS: INSIGHTS FROM MULTIVARIATE ANALYSIS OF 508 PROCEDURES
- Creators
- Pragyat FutelaTiffany J. WoelberNarut PrasitlumkumHina AminSuganya Arunachalam KarikalanKiyan HeybatiAishwarya PradeepAbhishek J. DeshmukhGurukripa N. Kowlgi
- Resource Type
- Abstract
- Publication Details
- Heart rhythm, Vol.21(5 Suppl), pp.S155-S155
- DOI
- 10.1016/j.hrthm.2024.03.567
- ISSN
- 1547-5271
- eISSN
- 1556-3871
- Language
- English
- Date published
- 05/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984961107602771
Metrics
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