PREMATURE CORONARY ARTERY DISEASE IN VERY YOUNG WOMEN: GENDER DOES NOT DISCRIMINATE

Pavida Pachariyanon; Joseph Golden; Wasawat Vutthikraivit; Kalgi A. Modi

doi:10.1016/S0735-1097(22)02149-0

Back

PREMATURE CORONARY ARTERY DISEASE IN VERY YOUNG WOMEN: GENDER DOES NOT DISCRIMINATE

Abstract

Open access

Peer reviewed

PREMATURE CORONARY ARTERY DISEASE IN VERY YOUNG WOMEN: GENDER DOES NOT DISCRIMINATE

Pavida Pachariyanon, Joseph Golden, Wasawat Vutthikraivit and Kalgi A. Modi

Journal of the American College of Cardiology, Vol.79(9 Supplement), p.1158

03/2022

DOI: 10.1016/S0735-1097(22)02149-0

Files and links (1)

url

https://doi.org/10.1016/S0735-1097(22)02149-0View

Published (Version of record) Open Access

Abstract

Background In the present study we aim to evaluate risk factors for premature coronary artery disease in patients aged ≤ 35 years undergoing coronary angiography (CAG). Methods Clinical records for 233 patients aged ≤ 35 years with angina or angina equivalent who underwent CAG from June 2002 to May 2015 at our institution were analyzed. The demographics, coronary risk factors, history of illicit drug use, biochemical profile, angiographic findings and long term clinical outcome were examined and compared between obstructive coronary artery disease (CAD) group (more than 70% luminal obstruction or 50-70% luminal obstruction with functional inducible ischemia) and nonobstructive CAD or normal coronary group. Results Mean age was 31.02 + 4.25, 37.34 % were female and 62.66% were African American. Out of 233 patients, 55 (23.60%) had obstructive CAD. Pack-year of smoking, family history of premature CAD and total cholesterol level was found to be significantly higher in obstructive CAD group as compared to non-obstructive CAD or normal coronary group [odds ratio 1.07; 95% confidence interval (CI) 1.01-1.14; p=0.032, odds ratio 8.76; 95% CI 3.26-23.52; p<0.001 and odds ratio 1.03; 95% CI 1.01-1.06; p=0.031, respectively]. There was no gender difference in the obstructive CAD group (17.24% vs 27.40%; p=0.077). Accumulative adverse cardiac event at 5 years was 42.49%, driven by recurrent angina and acute decompensated heart failure. 6.01% of patients died in 5 years, mainly in heart failure with reduced ejection fraction group. Conclusion Premature obstructive CAD was significantly associated with smoking intensity, family history of CAD and hypercholesterolemia. Premature atherosclerotic CAD affects equally young men and young women.

Details

Title: Subtitle: PREMATURE CORONARY ARTERY DISEASE IN VERY YOUNG WOMEN: GENDER DOES NOT DISCRIMINATE
Creators: Pavida Pachariyanon - Louisiana State University in Shreveport
Joseph Golden - Louisiana State University in Shreveport
Wasawat Vutthikraivit - Louisiana State University in Shreveport
Kalgi A. Modi - Louisiana State University in Shreveport
Resource Type: Abstract
Publication Details: Journal of the American College of Cardiology, Vol.79(9 Supplement), p.1158
DOI: 10.1016/S0735-1097(22)02149-0
ISSN: 0735-1097
eISSN: 1558-3597
Language: English
Date published: 03/2022
Academic Unit: Internal Medicine
Record Identifier: 9984695813402771

Metrics

3 Record Views