Abstract
PROSTAGLANDINS (PG) MODULATING RENAL BLOOD FLOW (RBF) AND PLASMA RENIN ACTIVITY (PRA) DURING FETAL LIFE
Pediatric research, Vol.14(8), pp.986-986
08/1980
DOI: 10.1203/00006450-198008000-00077
Abstract
The effect of PG synthesis inhibition by indomethacin (I) (5.7 ±0.70 mg/kg fetal wt., i.v. bolus) on RBF and intracortical blood flow distribution was studied in 8 chronically catheterized fetal lambs (117-137 days gestation; term 145 days) using 15μ microspheres. Following I urinary PGE and PGF decreased significantly (p<0.01) from 0.72±0.12 to 0.27±0.04 ng/min and from 0.93±0.16 to 0.36±0.09 ng/min respectively. Fetal blood pressure increased significantly from 40±1 to 45±2 mmHg (p<0.01) and heart rate decreased significantly from 173±5 to 142±6 beats/min (p<0.05). Fetal arterial pH, blood gases, Na+, K+ and Cl− remained within normal limits. A significant decrease in RBF and increase in glomerular filtration rate (GFR), filtration fraction (FF) and renal vascular resistance (RVR) were observed following I.
No change in intracortical blood flow distribution was seen following I. PRA decreased significantly from 6.3±1.2 to 3.1±0.7 ng/cc/hr following I (p<0.01). The present results suggest that during fetal life, renal PG's: a) have an important role in maintaining RBF by decreasing efferent arteriolar constriction and b) may modulate renin secretion.
Details
- Title: Subtitle
- PROSTAGLANDINS (PG) MODULATING RENAL BLOOD FLOW (RBF) AND PLASMA RENIN ACTIVITY (PRA) DURING FETAL LIFE
- Creators
- J R Matson - University of IowaJ E Robillard - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Pediatric research, Vol.14(8), pp.986-986
- Publisher
- WILLIAMS & WILKINS; BALTIMORE
- DOI
- 10.1203/00006450-198008000-00077
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 1
- Language
- English
- Date published
- 08/1980
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Medicine Administration; Stead Family Department of Pediatrics
- Record Identifier
- 9984774211302771
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