Abstract
Papillary Thyroid Cancer Margin Status Impact on Survival
Journal of the American College of Surgeons, Vol.223(4), pp.e185-e185
10/2016
DOI: 10.1016/j.jamcollsurg.2016.08.469
Abstract
Introduction
Margin status act as a significant prognostic factor in a number of malignancies. In this study, we aim to examine the impact of margin status on overall survival in patients with papillary thyroid carcinoma (PTC).
Methods
A retrospective cohort study utilizing the National Cancer Data Base, 2004–2012. The study population included adults (≥18 years) who underwent thyroid surgery for PTC, stages I–III. Subsequently, based on the margin status, the population classified into negative, microscope positive, and macroscopic positive margins.
Results
A total of 72,119 patients were included, of those 64,800 (89.9%) had negative margins, while 9.9% and 0.3% had microscopic and macroscopic positive margins, respectively. The median follow-up time was 43.7 months (interquartile range: 26.2 – 69.6). Higher prevalence of positive margins was identified in patients managed in low-volume hospitals [OR: 1.43, 95% CI: (1.34, 1.54)], or in intermediate-volume hospitals [OR: 1.34, 95% CI: (1.26, 1.43)]. As compared to patients with negative margins, positive margins did not significantly affect survival in patients with stage I – II (p=0.07). Patients with stage III and who had microscopic positive margins did not have significantly different survival [HR: 1.07, 95%CI: (0.84, 1.38)], while those with macroscopic positive margins had significantly lower survival [HR: 4.04, 95% CI: (1.50, 10.87)].
Conclusions
Patients managed in hospitals with lower experience are more likely to have positive margins following surgery. A macroscopic positive margin is a significant predicator of survival in patients with stage III PTC only.
Details
- Title: Subtitle
- Papillary Thyroid Cancer Margin Status Impact on Survival
- Creators
- Zaid Al-QurayshiSudesh Srivastav - Tulane UniversityEmad Kandil - Tulane University
- Resource Type
- Abstract
- Publication Details
- Journal of the American College of Surgeons, Vol.223(4), pp.e185-e185
- Publisher
- ELSEVIER SCIENCE INC
- DOI
- 10.1016/j.jamcollsurg.2016.08.469
- ISSN
- 1072-7515
- eISSN
- 1879-1190
- Language
- English
- Date published
- 10/2016
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984702899502771
Metrics
1 Record Views