Abstract
Post-Kidney Transplant Outcomes of Patients with Scleroderma from the Scientific Registry of Transplant Recipients (SRTR) Database, 1987-2024: TH-PO0952
Journal of the American Society of Nephrology, Vol.36(10S)
10/2025
DOI: 10.1681/ASN.2025hd0ersg1
Abstract
Background:
Systemic sclerosis (SSc) can lead to end-stage kidney disease (ESKD) requiring transplant, yet outcomes for SSc remain underexplored.
Methods:
Adult SSc patients (≥18 years) who underwent kidney transplantation (1987-2024) were identified from the SRTR database. Primary outcomes included patient survival and death-censored graft survival. Kaplan-Meier analysis was used to estimate survival functions, and multivariable Cox proportional hazards models were employed to identify factors associated with both outcomes.
Results:
Among 3,750,323 transplant recipients (3,817 with SSc), SSc patients were younger (median age: 33 vs. 49 yrs; p<0.001) and 54% males. OutcomesMortality: 1.0% (SSc) vs. 3.1% (p<0.001) Graft failure: 3.7% vs. 3.8% (p=0.818) Graft thrombosis: 1.2% vs. 0.8% (p=0.312) Infection: 1.2% vs. 3.2% (p=0.033) Chronic rejection: 6.1% vs. 6.9% (p=0.784) Acute rejection: 15.1% vs. 6.4% (p=0.003) SSc status was not significantly associated with mortality (HR 0.696; p=0.115) and graft failure (HR 0.92; p=0.474) after adjusting for female sex, recipient's and donor’s age, donor type, cold ischemic time, recipient’s Cr and pre-transplant dialysis. Cox interaction analysis revealed a statistically significant interaction between donor age and mortality in SSc (HR: 0.97; p=0.024). Figs. 1A and B shows results of survival analyses.
Conclusion:
Graft survival and mortality in SSc patients was comparable to patients without SSc. Donor age was linked to higher mortality overall, this effect was attenuated in SSc, suggesting other contributing factors that warrant further investigation.
Details
- Title: Subtitle
- Post-Kidney Transplant Outcomes of Patients with Scleroderma from the Scientific Registry of Transplant Recipients (SRTR) Database, 1987-2024: TH-PO0952
- Creators
- Farah YasminFrancis Perry WilsonSarat C. KuppachiAbhishek Kumar
- Resource Type
- Abstract
- Publication Details
- Journal of the American Society of Nephrology, Vol.36(10S)
- DOI
- 10.1681/ASN.2025hd0ersg1
- ISSN
- 1046-6673
- eISSN
- 1533-3450
- Publisher
- American Society of Nephrology
- Language
- English
- Date published
- 10/2025
- Academic Unit
- Stead Family Department of Pediatrics; Nephrology; Internal Medicine
- Record Identifier
- 9985019030202771
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