Abstract
Power Production During the Five Time Sit-to-Stand Test in Individuals with Multiple Sclerosis
Multiple sclerosis and related disorders, Vol.99, 106496
07/2025
DOI: 10.1016/j.msard.2025.106496
Abstract
Falling is a common problem in people with multiple sclerosis (PwMS) that can begin even before a clinical MS diagnosis. Many falls occur during transfer movements, making lower-body strength and power assessments valuable for evaluating fall risk. However, equipment needed for these assessments may be unavailable in some clinical settings, thus formulas estimating lower-body power during the five-times sit-to-stand test (5XSST) have been developed in non-MS populations. It's unknown whether these formulas accurately estimate force in PwMS or if lower-body power differs between MS fallers and non-fallers.
5XSST data was collected on a force plate from 29 PwMS and 27 age- and sex-matched neurotypical (NT) controls. Vertical ground reaction forces (vGRF) were recorded to quantify peak force, rate of force development, and lower-body power. Estimated power was calculated using an equation incorporating participant body mass, height, and task completion time. One-dimensional statistical parametric mapping compared vGRF profiles between PwMS and NT controls. Independent t-tests compared force metrics across groups and Pearson correlations assessed relationships between power measures.
PwMS displayed slower 5XSST completion times (p=0.011), reduced peak vGRF (p=0.011), a slower rate of force development (p<0.001), lower power (p=0.003), and a flatter force profile compared to NT controls. Estimated power, derived from kinematic and anthropometric variables, moderately correlated with instrumented power measures (r=0.53, p=0.003), with stronger correlations when the estimation equation incorporated leg length (r=0.59, p<0.001). Among PwMS, those who reported a prior fall demonstrated reduced instrumented (p=0.026) and estimated power (p=0.028) compared to non-fallers.
PwMS exhibit distinct weight transfer strategies during the 5XSST, with reduced lower-body power serving as a possible marker of heightened fall risk. These findings highlight the need for rehabilitation strategies that improve lower-body power and for clinical measures that accurately assess power deficits and fall risk in PwMS.
Details
- Title: Subtitle
- Power Production During the Five Time Sit-to-Stand Test in Individuals with Multiple Sclerosis
- Creators
- Christopher M. Patrick - Colorado State UniversityIsaac E. Bast - Colorado State UniversityMatthew W. Scarsbrook - Colorado State UniversityClayton W. Swanson - Malcom Randall VA Medical CenterBrett W. Fling - Colorado State UniversityKristin A. Johnson - Colorado State University
- Resource Type
- Abstract
- Publication Details
- Multiple sclerosis and related disorders, Vol.99, 106496
- DOI
- 10.1016/j.msard.2025.106496
- ISSN
- 2211-0348
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 07/2025
- Academic Unit
- Physical Therapy and Rehabilitation Science; Injury Prevention Research Center
- Record Identifier
- 9985134038302771
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