Abstract
Preshearing effects on viscoelastic properties of collagen-based vocal fold injectables
The Journal of the Acoustical Society of America, Vol.120(5_Supplement), pp.3351-3351
11/01/2006
DOI: 10.1121/1.4781424
Abstract
A criterion for developing a biomaterial is that its viscoelastic properties correspond to native tissues. This criterion is particularly important for vocal fold tissues. Collagen-based injectables are routinely used to repair paralyzed or scarred vocal folds and restore vocalization, yet reported viscoelastic properties are inconsistent. The present study evaluated the effects of preshearing samples on their viscoelastic measurements. Non-cross-linked bovine collagen (Zyderm IITM) and micronized dermal tissue (CymetraTM) were presheared by extruding directly through a mechanically operated syringe with different needle sizes. Preshear rates ranged from 31 to 5600/s for orifice radii of 1.21 to 0.0955 mm, respectively. Sandpaper-coated, parallel plate attachments on a stress-controlled rheometer were used to measure elastic moduli and dynamic viscosities from 0.01 to 10 Hz. A 3–10-fold reduction in elastic modulus and a 2–4-fold reduction in dynamic viscosity occurred for preshear rates exceeding 1000/s compared to rates of 31 and 131/s. These results suggest a change in the molecular structure and the viscoelastic compatibility of vocal fold injectables when sufficiently presheared. [Work supported by NIH.]
Details
- Title: Subtitle
- Preshearing effects on viscoelastic properties of collagen-based vocal fold injectables
- Creators
- Sarah A. Klemuk - University of IowaIngo R. Titze - University of Iowa
- Resource Type
- Abstract
- Publication Details
- The Journal of the Acoustical Society of America, Vol.120(5_Supplement), pp.3351-3351
- DOI
- 10.1121/1.4781424
- ISSN
- 0001-4966
- eISSN
- 1520-8524
- Language
- English
- Date published
- 11/01/2006
- Academic Unit
- School of Music; Communication Sciences and Disorders
- Record Identifier
- 9984719563202771
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