Abstract
Radon exposure and gestational diabetes mellitus: the nuMoM2b study
Environmental health perspectives. Supplements, Vol.2024(1)
08/15/2024
DOI: 10.1289/isee.2024.0948
Abstract
Abstract only
BACKGROUND AND AIM[|]To examine the association between county-level radon exposure and gestational diabetes mellitus (GDM) in a cohort of nulliparous pregnant individuals in the US, while also examining inflammation and insulin sensitivity as potential pathways.[¤]METHOD[|]This is a secondary ecological analysis of data from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be (nuMoM2b) study (n=10038). We utilized county-level radon data estimated by the Lawrence Berkeley National Laboratory, which were based on the EPA's short-term indoor radon assessments conducted during the 1990s. We categorized radon levels using the EPA's recommended action level (2 pCi/L) and, due to a large number in the <2 pCi/L category, further divided it, resulting in three exposure groups: <1, 1–2, and≥2 pCi/L. The primary outcome was GDM. We secondarily examined C-reactive protein (CRP) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), which were available for a subset of participants who consented to the follow-up study. We classified CRP levels as either low risk or intermediate-to-high risk for global cardiovascular disease using a cutoff of 1 mg/L. Multiple logistic regression was used to assess the associations of interest.[¤]RESULTS[|]After adjusting for demographic, lifestyle factors (e.g., smoking), clinical variables, and PM2.5, women from the highest radon group (≥2 pCi/L) had higher odds of developing GDM compared to those from the lowest radon group (<1 pCi/L) (OR: 1.40; 95% CI: 1.04, 1.87). Radon exposure was also associated with higher odds of having CRP above 1 mg/L (OR: 1.49; 95% CI: 1.15, 1.93 for radon group ≥2 pCi/L). No significant association between radon exposure and HOMA-IR was observed.[¤]CONCLUSIONS[|]Findings from this cohort study support the hypothesis that higher radon exposure is associated with higher odds of GDM. Further studies are needed to confirm the results and understand the underlying mechanisms.[¤]
Details
- Title: Subtitle
- Radon exposure and gestational diabetes mellitus: the nuMoM2b study
- Creators
- Yijia Zhang - Columbia UniversityMeghan Angley - Columbia UniversityLiping Lu - Columbia UniversityBrian J Smith - University of IowaWilliam Grobman - The Ohio State UniversityBlair J Wylie - Columbia University Irving Medical CenterUma Reddy - Columbia UniversityKa Kahe - Columbia University Irving Medical Center
- Resource Type
- Abstract
- Publication Details
- Environmental health perspectives. Supplements, Vol.2024(1)
- DOI
- 10.1289/isee.2024.0948
- ISSN
- 1078-0475
- eISSN
- 2169-2181
- Language
- English
- Date published
- 08/15/2024
- Academic Unit
- Biostatistics; Holden Comprehensive Cancer Center
- Record Identifier
- 9984696760202771
Metrics
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