Rationally Designed Proton Channel Inhibitors Reveal a Druggable Pocket in a Voltage-sensing Domain

Abstract

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Chang Zhao, Liang Hong, Saleh Riahi, Jason D Galpin, Christopher A Ahern, Douglas J Tobias and Francesco Tombola

Biophysical journal, Vol.118(3), pp.111a-111a

02/07/2020

DOI: 10.1016/j.bpj.2019.11.754

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conference abstract

Title: Subtitle: Rationally Designed Proton Channel Inhibitors Reveal a Druggable Pocket in a Voltage-sensing Domain
Creators: Chang Zhao - Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA
Liang Hong - Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA
Saleh Riahi - Department of Chemistry, University of California Irvine, Irvine, CA, USA
Jason D Galpin - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA
Christopher A Ahern - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA
Douglas J Tobias - Department of Chemistry, University of California Irvine, Irvine, CA, USA
Francesco Tombola - Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA
Resource Type: Abstract
Publication Details: Biophysical journal, Vol.118(3), pp.111a-111a
DOI: 10.1016/j.bpj.2019.11.754
ISSN: 0006-3495
eISSN: 1542-0086
Publisher: Elsevier Inc
Language: English
Date published: 02/07/2020
Academic Unit: Molecular Physiology and Biophysics; Iowa Neuroscience Institute
Record Identifier: 9984071639402771

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