Abstract
Relationship between Pulmonary Airflow and Resistance in Patients with Airway Narrowing Using An 1-D Network Resistance and Compliance Model
Bulletin of the American Physical Society, Vol.61(20), BAPS.2016.DFD.R16.5
Annual Meeting of the American Physical Society Division of Fluid Dynamics (APS DFD) (Portland, Oregon, 11/20/2016 - 11/22/2016)
11/2016
Abstract
To predict the proper relationship between airway resistance and regional airflow, we proposed a novel 1-D network model for airway resistance and acinar compliance. First, we extracted 1-D skeletons at inspiration images, and generated 1-D trees of CT unresolved airways with a volume filling method. We used Horsfield order with random heterogeneity to create diameters of the generated 1-D trees. We employed a resistance model that accounts for kinetic energy and viscous dissipation (Model A). The resistance model is further coupled with a regional compliance model estimated from two static images (Model B). For validation, we applied both models to a healthy subject. The results showed that Model A failed to provide airflows consistent with air volume change, whereas Model B provided airflows consistent with air volume change. Since airflows shall be regionally consistent with air volume change in patients with normal airways, Model B was validated. Then, we applied Model B to severe asthmatic subjects. The results showed that regional airflows were significantly deviated from air volume change due to airway narrowing. This implies that airway resistance plays a major role in determining regional airflows of patients with airway narrowing.
Details
- Title: Subtitle
- Relationship between Pulmonary Airflow and Resistance in Patients with Airway Narrowing Using An 1-D Network Resistance and Compliance Model
- Creators
- Sanghun Choi - University of IowaJiwoong Choi - University of Iowa, Mechanical EngineeringEric A Hoffman - University of Iowa, RadiologyChing-Long Lin - University of Iowa, Mechanical Engineering
- Resource Type
- Abstract
- Publication Details
- Bulletin of the American Physical Society, Vol.61(20), BAPS.2016.DFD.R16.5
- Conference
- Annual Meeting of the American Physical Society Division of Fluid Dynamics (APS DFD) (Portland, Oregon, 11/20/2016 - 11/22/2016)
- Publisher
- American Physical Society
- ISSN
- 0003-0503
- Grant note
- Support for this study was provided, in part, by NIH Grants U01 HL114494, R01 HL094315, R01 HL112986, and S10 RR022421.
- Language
- English
- Date published
- 11/2016
- Academic Unit
- Internal Medicine; Mechanical Engineering; Radiology; Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984571658402771
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