Abstract
Relationship between total peripheral resistance and measures of central artery wave reflection
The FASEB journal, Vol.24(S1), pp.594.7-594.7
04/2010
DOI: 10.1096/fasebj.24.1_supplement.594.7
Abstract
We examined the relationship between total peripheral resistance (TPR) and central artery pressure and indices of wave reflection in 16 subjects (10F/6M; 26 ± 1 yr). Non‐invasive aortic pressure waveforms were synthesized from high‐fidelity radial pressure waveforms obtained from applanation tonometry of the radial artery. Radial blood pressure (BP) was calibrated from brachial artery BP (catheter). Central artery pressures, aortic augmentation index (AIa), roundtrip travel time of the reflected wave to and from the periphery (Δtp; inverse of pulse wave velocity), and wasted left ventricular energy (Ew) were calculated from the generated aortic pressure waveform. Cardiac output (CO) was measured using an open‐circuit acetylene uptake technique and used to calculate total peripheral resistance (mean arterial pressure/CO). TPR was positively related to aortic pulse pressure (r = 0.49), augmented pressure of the central artery wave (r = 0.60), pulse pressure amplification (r =0.54), AIa (r = 0.53), and Ew (r = 0.66), (P < 0.05 for all). Additionally, TPR was inversely related to Δtp (r = − 0.51, P < 0.05). Our data suggests that increased levels of TPR are related to measures of central artery pressure, wave reflection characteristics and indices of central artery stiffness.
Supported by NIH K23 DK‐082424 (TBC), AHA 2170087(ECH) and CTSA RR‐024150
Details
- Title: Subtitle
- Relationship between total peripheral resistance and measures of central artery wave reflection
- Creators
- John RA Shepherd - Mayo ClinicEmma C. Hart - Mayo ClinicTimothy B. Curry - Mayo Clinic in FloridaNisha Charkoudian - Mayo Clinic in FloridaMichael J. Joyner - Mayo ClinicDarren P. Casey - Mayo Clinic in Florida
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.24(S1), pp.594.7-594.7
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.24.1_supplement.594.7
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- AHA (2170087) CTSA (RR‐024150) NIH (K23 DK‐082424)
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984294935702771
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