Abstract
Respiratory sensitivity to Co2 as a trait of familial panic disorder
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.96(4), p.558
08/07/2000
Abstract
Subjects were 18 to 35 years old and had neither a current DSM-IV diagnosis nor a lifetime history of panic attacks. Those at high risk for panic disorder (HR-P, n = 46) had a first-degree relative with treated panic disorder while low-risk controls (LR-C, n = 39) did not. Respiratory measurements were taken continuously while subjects breathed room air through an attached mask for 3 minutes and, subsequently, while they breathed a 5% CO2/air mixture for an additional 3 minutes. HR-P subjects did not differ from controls by group means of the principal measure of respiratory response, change in minute volume (MV) during CO2 inhalation. However, these values assumed clearly different distributions in the two groups. Fifteen (32.6%) of the HR-P subjects showed a paradoxical decrease in minute volume while breathing CO2 and 6 (13%) displayed a particularly rapid increase in MV. Only 1 (2.6%) of the control subjects had a negative MV slope and none had a high value (2 = 12.3, df = 1, p < 0.001; p = 0.021, Fisher's Exact test, respectively). Though the subjects with high MV increases also described a greater increases in anxiety after breathing CO2, a regression analyses indicated that the MV increase was the more important in discriminating high-risk subjects from controls. These results suggest that respiratory sensitivity to CO2 inhalation is operative in the familial transmission of panic disorder.
Details
- Title: Subtitle
- Respiratory sensitivity to Co2 as a trait of familial panic disorder
- Creators
- W. Coryell - University of Iowa, College of Medicine, Psychiatry Research 2-205 MEB, United StatesA. Fyer - University of Iowa, College of Medicine, Psychiatry Research 2-205 MEB, United StatesJ. Martinez - University of Iowa, College of Medicine, Psychiatry Research 2-205 MEB, United StatesD. Pine - University of Iowa, College of Medicine, Psychiatry Research 2-205 MEB, United StatesS. Arndt - University of Iowa, College of Medicine, Psychiatry Research 2-205 MEB, United States
- Resource Type
- Abstract
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.96(4), p.558
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Publisher
- Wiley
- Comment
- (2000), Abstracts of Presentations: Eighth World Congress on Psychiatric Genetics, Versailles, France. Am. J. Med. Genet., 96: 538-559. https://doi.org/10.1002/1096-8628(20000807)96:4<538::AID-AJMG7>3.0.CO;2-I
- Language
- English
- Date published
- 08/07/2000
- Academic Unit
- Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9985132189102771
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