Abstract
Restoration of blood flow to hypoperfused contracting muscle is related to changes in vascular resistance
The FASEB journal, Vol.24(S1), pp.1039.4-1039.4
04/2010
DOI: 10.1096/fasebj.24.1_supplement.1039.4
Abstract
We examined the relationship between flow restoration and vascular resistance in the exercising forearm during hypoperfusion caused by balloon inflation in the brachial artery. 75 trials (with and without nitric oxide synthase (NOS) inhibition) were analyzed. Each included forearm exercise (10% or 20% of max), exercise with inflation, and exercise after deflation (3 min each). FBF (ultrasound), local (brachial artery; BAP), and systemic arterial pressure (SAP) were measured. FBF restoration during balloon inflation was calculated as (steady state inflation plus exercise value – nadir)/[steady state exercise (control) value‐nadir] and expressed as % recovery of FBF. Balloon resistance [(SAP‐BAP)/flow] and vascular resistance (BAP/flow) were expressed as the % change from onset of inflation to end inflation. The % recovery of FBF was strongly related to the drop in vascular resistance for all trials (r = 0.664, P <0.001). This relationship was unaffected by NOS inhibition (n= 27; r = 0.623, P < 0.001 vs. control n = 48; r = 0.685, P < 0.001). The relationship was also stronger with increasing exercise intensity (r = 0.57 vs. 0.704). The % recovery of FBF was unrelated to changes in balloon resistance under any condition. Thus, flow restoration is determined primarily by the fall in local vascular resistance during forearm exercise with hypoperfusion.
Supported by NIH HL‐46493 (MJJ), AR‐55819 (DPC) and RR‐024150.
Details
- Title: Subtitle
- Restoration of blood flow to hypoperfused contracting muscle is related to changes in vascular resistance
- Creators
- Darren P. Casey - Mayo Clinic in FloridaMichael J. Joyner - Mayo Clinic
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.24(S1), pp.1039.4-1039.4
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.24.1_supplement.1039.4
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- NIH (HL‐46493 (MJJ); AR‐55819 (DPC); RR‐024150)
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984295032902771
Metrics
43 Record Views