Abstract
SU-F-J-222: Using PET Imaging to Evaluate Proliferation and Blood Flow in Irradiated and Non-Irradiated Bone Marrow 1 Year After Chemoradiation Therapy
Medical physics (Lancaster), Vol.43(6), pp.3460-3460
06/2016
DOI: 10.1118/1.4956130
Abstract
Purpose:
To compare proliferation and blood flow in pelvic and thoracic bone marrow 1 year after pelvic chemoradiation.
Methods:
Sixteen pelvic cancer patients were enrolled in an IRB-approved protocol to acquire FLT PET images during radiation therapy simulation (baseline) and 1 year after chemoradiation therapy. Three subjects also had optional O-15 water PET images acquired 1 year after chemoradiation therapy. Baseline FLT PET images were used to create IMRT plans to spare pelvic bone marrow identified as regions with FLT SUV ≥ 2 without compromising PTV coverage or OAR sparing. Marrow VOIs were defined using a 50% maximum pixel value threshold on baseline FLT PET images (VIEW, PMOD version 3.5) in the sacrum and thoracic spine representing irradiated and non-irradiated regions, respectively. FLT PET and O-15 water PET images acquired 1 year after therapy were co-registered to baseline images (FUSION PMOD) and the same VOIs were used to measure proliferation (FLT SUV) and blood flow (O-15 water uptake). Separate image-based input functions were used for blood flow quantitation in each VOI.
Results:
Mean 1 year FLT SUV in sacral and thoracic VOIs for were 1.1 ± 0.4 and 6.5 ± 1.7, respectively for N = 16 subjects and were 1.2 ± 0.2 and 5.6 ± 1.6, respectively for N = 3 subjects who also underwent O-15 water imaging. Blood flow measures in equivalent sacral and thoracic marrow regions (N = 3) were 21.3 ± 8.7 and 18.3 ± 4.9 mL/min/100mL respectively.
Conclusion:
Decreased bone marrow proliferation measured by FLT SUV does not appear to correspond to decreased blood flow as measured by O-15 water PET imaging. Based on this small sample at a single time point, reduced blood supply does not explain reductions in bone marrow proliferative activity 1 year after chemoradiation therapy.
Details
- Title: Subtitle
- SU-F-J-222: Using PET Imaging to Evaluate Proliferation and Blood Flow in Irradiated and Non-Irradiated Bone Marrow 1 Year After Chemoradiation Therapy
- Creators
- S McGuire - University of IowaL Ponto - University of IowaY Menda - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Medical physics (Lancaster), Vol.43(6), pp.3460-3460
- DOI
- 10.1118/1.4956130
- ISSN
- 0094-2405
- eISSN
- 2473-4209
- Number of pages
- 1
- Date published
- 06/2016
- Academic Unit
- Interdisciplinary Studies Program; Art and Art History; Radiology; Radiation Oncology
- Record Identifier
- 9984314164302771
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