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SUN-602 Temporal Trends in Mortality related to Obesity with Diabetes Mellitus in The United States: A 21 year retrospective analysis of CDC-Wonder database
Abstract   Peer reviewed

SUN-602 Temporal Trends in Mortality related to Obesity with Diabetes Mellitus in The United States: A 21 year retrospective analysis of CDC-Wonder database

Ishtiaq Ahmad, Muhammad Usman Haider, Ayeza Nawaz, Arham Khalid Farooq, Shamikha Cheema, Laiba Sarfraz, Muhammad Faique Hassan, Daniah Rizwan, Mian Zahid Jan Kakakhel, Hasan Ilyas, …
Journal of the Endocrine Society, Vol.9(Supplement_1)
10/22/2025
DOI: 10.1210/jendso/bvaf149.1253
PMCID: PMC12543803

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Abstract

Introduction/Background: Rates of obesity are increasing world-wide with an estimation of about 1 billion people projected to be obese by 2030, if the trends remain constant. Obesity is considered one of the most closely associated factors of diabetes mellitus. Therefore, it is expected that with the increasing rates of obesity, the rates of diabetes mellitus will also be rising. Our study aims to analyze changes in mortality from 1999 to 2020 in patients aged 15-85+ with obesity and diabetes mellitus in the United States. Methods: We retrospectively analyzed CDC-WONDER database to investigate temporal trends in mortality related to obesity with diabetes mellitus from 1999 to 2020.The crude mortality rates(CMR) per 100,000 and age-adjusted mortality rates(AAMRs) per 100,000 were analyzed, and Annual Percentage Change(APC) was calculated using the Joinpoint regression model across variations in demographics (sex, race), urbanization,10-year age groups and regional subgroups. Results: Between 1999 and 2020, around 234577 deaths were reported from obesity with diabetes mellitus across the 15-85+ age group. The AAMR gradually increased from 1.8 in 1999 to 5.2 in 2018 (APC:4.98; 95%CI:4.43-5.53) after which it abruptly increased to 8.8 in 2020 (APC:23.80; 95%CI: 10.65-38.52). First, females had a higher AAMR than males till 2007 after which males had a higher AAMR than females till 2020. Non-Hispanic(NH) Black or African American had the highest overall AAMR(6.4), followed by NH American Indian/Alaska Native(6.1), NH white(3.8), Hispanic or Latino(3.5) and NH Asian or Pacific Islander adults(1). Rural areas had consistently higher AAMR than the urban areas. AAMR also varied by the region. Midwest region had the highest overall AAMR(4.4),followed by West(4.3),South(4) and Northeast(3.3). Crude mortality rates were highest for the 65-74 years age group. The crude mortality rates (CMR) for all the 10-year age groups abruptly increased from 2019-2020 .The location of death varied, with 48.00% in medical facilities, 37.90% at home, 1.40% in hospices, 8.40% in nursing home/long-term care facilities and 4.10% at other/unknown places. Conclusion: An overall rise in mortality has been observed in obesity with diabetes mellitus in the United States, with the greatest surge in 2020. The need for healthcare policy changes and targeted public health interventions focusing on high risk population are needed to prevent increasing levels of mortality among patients of diabetes mellitus with obesity. Clinicians should consider managing weight loss in their patients especially those with high frequency of visits and nutritional support. Early screening and prevention in patients will be an antagonizing factor for the rising mortality rates of such patients. Presentation: Sunday, July 13, 2025
 Diabetes Obesity Age groups Hispanic Americans Mortality Trends Weight control

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