Statin or ACE Inhibitor Improve Vascular Dysfunction in Zucker Obese and ZDF Rats

Christine L. Oltman; Travis L. Kleinschmidt; Mark A. Yorek

doi:10.1096/fasebj.21.6.A1196-d

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Statin or ACE Inhibitor Improve Vascular Dysfunction in Zucker Obese and ZDF Rats

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Statin or ACE Inhibitor Improve Vascular Dysfunction in Zucker Obese and ZDF Rats

Christine L. Oltman, Travis L. Kleinschmidt and Mark A. Yorek

The FASEB journal, Vol.21(6), pp.A1196-A1197

2007

DOI: 10.1096/fasebj.21.6.A1196-d

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Abstract

Previous studies have shown vascular dysfunction in small coronary and mesenteric arteries from Zucker obese and Zucker Diabetic Fatty (ZDF) rats. Our hypothesis is that treatment with HMG‐CoA reductase inhibitor (statin) or angiotension converting enzyme inhibitor (ACEi) will improve vascular dysfunction in these rat models. Zucker obese and ZDF rats were treated with Rosuvastatin (50mg/Kg/day) or Enalapril (40mg/Kg/day) for 12 weeks. We examined small ventricular and mesenteric vessels using an isolated vessel preparation. Acetylcholine (Ach, 10‐10–10‐4 M) dilation was evaluated after U46619 constriction. Results: % Relaxation to 10 ?M Ach, (n). Ach responses were attenuated in both vascular beds from Zucker obese and ZDF rats compared to vessels from lean rats. Ach responses were augmented in vessels from statin or ACEi treated rats, compared to vessels from untreated rats. Endothelial dysfunction was improved when Zucker, and to a lesser degree when ZDF rats were treated with statin or ACEi suggesting more aggressive therapy is needed when hyperglycemia is involved. Supported by VA Merits to Drs. Oltman and Yorek.

Details

Title: Subtitle: Statin or ACE Inhibitor Improve Vascular Dysfunction in Zucker Obese and ZDF Rats
Creators: Christine L. Oltman - University of Iowa
Travis L. Kleinschmidt - Cardiovascular ResearchVeterans Administration Medical CenterRoom 204, Building 40, 601 Highway 6 WestIowa CityIA52246
Mark A. Yorek - University of Iowa
Resource Type: Abstract
Publication Details: The FASEB journal, Vol.21(6), pp.A1196-A1197
DOI: 10.1096/fasebj.21.6.A1196-d
ISSN: 0892-6638
eISSN: 1530-6860
Publisher: The Federation of American Societies for Experimental Biology
Number of pages: 1
Grant note: VA Merits to Drs. Oltman and Yorek
Language: English
Date published: 2007
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984363263602771

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