Abstract
Surgical debulking improves survival in high-grade serous carcinoma regardless of platinum sensitivity
Gynecologic oncology, Vol.162, pp.S54-S55
08/2021
DOI: 10.1016/S0090-8258(21)00747-2
Abstract
We aimed to assess whether patients who underwent primary optimal cytoreduction experienced improved survival regardless of platinum sensitivity.
We performed a retrospective, case-control study using our institution's ovarian cancer database to evaluate the effect of optimal cytoreduction on advanced stage, high grade serous ovarian cancer. Patients’ characteristics were compared using logistic regression and both univariate and multivariate Cox-proportional hazard regression. Validation of the model was then performed within The Cancer Genome Atlas (TCGA) database. [Display omitted]
A total of 470 patients were assessed for inclusion. A total of 234 patients were included as responders to chemotherapy and 98 were included as non-responders. Significant survival characteristics were identified and included in the multivariate analysis. Figure 2 demonstrates independent predictors of survival. Kaplan-Meier survival curves showed improved survival both for patients who were responders to chemotherapy as well as optimal cytoreduction (Figure 3; p<0.001). Log-rank analysis demonstrated improved survival for patients receiving optimal cytoreduction among both non-responders and responders (p<0.001).
Our analysis shows that patients who undergo primary optimal cytoreduction have a survival benefit regardless of their response to chemotherapy. Our model is well-validated within the TCGA database. Therefore, optimal primary cytoreduction should be considered, even in patients with advanced disease. If we are able to someday predict whether or not patients will respond to chemotherapy, cytoreductive surgery should still be considered a part of the treatment of non-responders.
Details
- Title: Subtitle
- Surgical debulking improves survival in high-grade serous carcinoma regardless of platinum sensitivity
- Creators
- Nicholas Cardillo - University of IowaRei Christian Calma - University of IowaYasmin Lyons - University of IowaMichael Goodheart - University of IowaJesus Gonzalez Bosquet - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Gynecologic oncology, Vol.162, pp.S54-S55
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0090-8258(21)00747-2
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Language
- English
- Date published
- 08/2021
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984386254102771
Metrics
26 Record Views