Abstract
Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms
Sleep medicine reviews, Vol.62, pp.101595-101595
04/2022
DOI: 10.1016/j.smrv.2022.101595
PMCID: PMC9064929
PMID: 35158305
Abstract
Sleep disturbances (SD) accompany many neurodevelopmental disorders, suggesting SD is a transdiagnostic process that can account for behavioral deficits and influence underlying neuropathogenesis. Autism Spectrum Disorder (ASD) comprises a complex set of neurodevelopmental conditions characterized by challenges in social interaction, communication, and restricted, repetitive behaviors. Diagnosis of ASD is based primarily on behavioral criteria, and there are no drugs that target core symptoms. Among the co-occurring conditions associated with ASD, SD are one of the most prevalent. SD often arises before the onset of other ASD symptoms. Sleep interventions improve not only sleep but also daytime behaviors in children with ASD. Here, we examine sleep phenotypes in multiple model systems relevant to ASD, e.g., mice, zebrafish, fruit flies and worms. Given the functions of sleep in promoting brain connectivity, neural plasticity, emotional regulation and social behavior, all of which are of critical importance in ASD pathogenesis, we propose that synaptic dysfunction is a major mechanism that connects ASD and SD. Common molecular targets in this interplay that are involved in synaptic function might be a novel avenue for therapy of individuals with ASD experiencing SD. Such therapy would be expected to improve not only sleep but also other ASD symptoms.
Details
- Title: Subtitle
- Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms
- Creators
- Fusun Doldur-Balli - University of PennsylvaniaToshihiro Imamura - Children's Hospital of PhiladelphiaOlivia J. Veatch - University of Kansas Medical CenterNaihua N. Gong - University of PennsylvaniaDiane C. Lim - University of MiamiMichael P. Hart - University of PennsylvaniaTed Abel - University of IowaMatthew S. Kayser - University of PennsylvaniaEdward S. Brodkin - University of PennsylvaniaAllan I. Pack - University of Pennsylvania
- Resource Type
- Abstract
- Publication Details
- Sleep medicine reviews, Vol.62, pp.101595-101595
- DOI
- 10.1016/j.smrv.2022.101595
- PMID
- 35158305
- PMCID
- PMC9064929
- NLM abbreviation
- Sleep Med Rev
- ISSN
- 1087-0792
- eISSN
- 1532-2955
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 04/2022
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984293558302771
Metrics
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