Abstract
TCT-444 Mid to Long-Term Outcomes of Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Severe Aortic Stenosis: A Systematic Review and Meta-Analysis
Journal of the American College of Cardiology, Vol.82(17 Suppl), pp.B178-B179
10/2023
DOI: 10.1016/j.jacc.2023.09.453
Abstract
Background
Transcatheter aortic valve replacement (TAVR) is an established alternative to surgical aortic valve replacement (SAVR) for high-risk surgical patients with severe aortic stenosis (AS). Recently, TAVR has been extended to low-risk patients, but there are limited pooled data on its long-term outcomes. We conducted a meta-analysis, including the mid-term and long-term results of ongoing randomized control trials (RCTs) comparing TAVR vs SAVR outcomes in low-risk patients.
Methods
We comprehensively searched MEDLINE, Cochrane, Embase, and clinicaltrials.gov. After the screening, the included RCTs were analyzed using the random-effects model. Odds ratios with 95% CIs were calculated for the outcomes. Follow-up was classified as short (30 days), mid (1-2 years), and long-term (>2 years).
Results
Four RCTs with 2,812 participants were included, with follow-up ranging from 1 year to 5 years. The results showed that TAVR was non-inferior to SAVR regarding both mid to long-term and short-term all-cause mortality. TAVR reduced the odds of atrial fibrillation significantly as compared with SAVR. However, the odds of permanent pacemaker implantation were significantly higher for TAVR as compared with SAVR. The odds for aortic valve reintervention, endocarditis, myocardial infarction, and stroke after the intervention were insignificant.
Details
- Title: Subtitle
- TCT-444 Mid to Long-Term Outcomes of Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Severe Aortic Stenosis: A Systematic Review and Meta-Analysis
- Creators
- Muhammad Adil Afzal - St. Joseph’s University Medical CenterNoman Khalid - St. Joseph’s University Medical CenterMuhammad Abdullah - Shaikh Zayed HospitalShayee Hasan - St. Joseph’s University Medical CenterMubariz Hassan - Howard University HospitalSherif Elkattawy - St. Joseph’s University Medical CenterKevin Lipat - St. Joseph’s University Medical CenterRahul Vasudev - St. Joseph’s University Medical Center
- Resource Type
- Abstract
- Publication Details
- Journal of the American College of Cardiology, Vol.82(17 Suppl), pp.B178-B179
- DOI
- 10.1016/j.jacc.2023.09.453
- ISSN
- 0735-1097
- Language
- English
- Date published
- 10/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984920837302771
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