THE IMPACT OF ATRIAL FIBRILLATION BURDEN ON CRYOBALLOON ABLATION OUTCOMES FOR PAROXYSMAL ATRIAL FIBRILLATION

Abhishek Bose; Parag Anilkumar Chevli; Zeba Hashmath; Ajay K. Mishra; Gregory Berberian; Ghasan Ahmad; Jerzy Januszkiewicz; Douglas Laidlaw

doi:10.1016/S0735-1097(20)31084-6

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THE IMPACT OF ATRIAL FIBRILLATION BURDEN ON CRYOBALLOON ABLATION OUTCOMES FOR PAROXYSMAL ATRIAL FIBRILLATION

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THE IMPACT OF ATRIAL FIBRILLATION BURDEN ON CRYOBALLOON ABLATION OUTCOMES FOR PAROXYSMAL ATRIAL FIBRILLATION

Abhishek Bose, Parag Anilkumar Chevli, Zeba Hashmath, Ajay K. Mishra, Gregory Berberian, Ghasan Ahmad, Jerzy Januszkiewicz and Douglas Laidlaw

Journal of the American College of Cardiology, Vol.75(11 Supplement 1), pp.457-457

03/24/2020

DOI: 10.1016/S0735-1097(20)31084-6

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Abstract

Background Cryoballoon ablation (CBA) is an effective therapy for patients with paroxysmal atrial fibrillation (AF) refractory to drug therapy. However, initial CBA is successful in only 70% of patients. Over time, greater AF burden leads to irreversible electro-anatomical changes in the left atrium. However, its role in contributing to recurrence of atrial arrhythmias (AA) following CBA for paroxysmal AF is unclear. Methods We followed 103 patients (Age 60.6 ± 9.1, 29% women) with paroxysmal AF undergoing CBA for one year post procedure. Recurrence was assessed by documented AA on EKG or any form of long term cardiac rhythm monitoring. AF burden was calculated based on duration of diagnosis of paroxysmal AF prior to CBA. A multivariate cox proportional hazard model was used to assess if AF burden predicted risk of AA recurrence. Results After a one year follow up, 19 (18.4%) participants developed recurrence of AA. Patients were dichotomized based on duration of diagnosis being greater or less than the median for all subjects (1035 days). Baseline demographics were similar between the two groups. On a multivariate model adjusted for baseline demographics and risk factors for AF, longer duration of paroxysmal AF diagnosis did not predict recurrence of AA following CBA (Table, p=0.17). Similarly, on Kaplan-Meier analysis longer duration did not predict time to first recurrence of AA (Figure, p=0.18). Conclusion In patients with paroxysmal AF, a greater AF burden did not predict recurrence of AA following CBA.

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Title: Subtitle: THE IMPACT OF ATRIAL FIBRILLATION BURDEN ON CRYOBALLOON ABLATION OUTCOMES FOR PAROXYSMAL ATRIAL FIBRILLATION
Creators: Abhishek Bose - Saint Vincent Hospital
Parag Anilkumar Chevli - Saint Vincent Hospital
Zeba Hashmath - Saint Vincent Hospital
Ajay K. Mishra - Saint Vincent Hospital
Gregory Berberian - Saint Vincent Hospital
Ghasan Ahmad - Saint Vincent Hospital
Jerzy Januszkiewicz - Saint Vincent Hospital
Douglas Laidlaw - Saint Vincent Hospital
Resource Type: Abstract
Publication Details: Journal of the American College of Cardiology, Vol.75(11 Supplement 1), pp.457-457
DOI: 10.1016/S0735-1097(20)31084-6
ISSN: 0735-1097
Language: English
Date published: 03/24/2020
Academic Unit: Internal Medicine
Record Identifier: 9985222831102771

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