Abstract
TLR-4 Modulates Cardiac Response to Stress: Insights from High Fat Diet and Pressure Overload
Obesity (Silver Spring, Md.), Vol.31(S2), pp.108-108
11/01/2023
Abstract
Background: Stresses such as high fat diet (HFD) and pressure overload caused by abdominal aortic constriction (AAC) have been associated with increased cardiac hypertrophy and fibrosis. Toll-like receptor 4 (TLR4) has been proposed to have a protective effect against these stresses, but contradictory research findings exist. This study aimed to investigate the impact of TLR4 on cardiac histology and physiology under these stressors.
Methods: TLR4-deficient (TLR4−/−) and wild-type (WT) mice on a C57Blk/6 J background were subjected to either HFD or normal diet (ND) for 28 weeks. Another group of mice underwent AAC or a sham procedure and were followed up for 84 days. Cardiac function was assessed through histological examination and echocardiography in all mice.
Results: TLR4−/− mice demonstrated a reduction in cardiac hypertrophy and fibrosis following long-term HFD exposure compared to ND, without affecting cardiac function. Conversely, TLR4 deficiency proved detrimental to the heart under pressure overload induced by AAC, leading to decreased ejection fraction (EF%) and increased end-systolic volume (ESV). This phenotype was associated with an upregulation of activating transcription factor 3 (ATF3), suggesting an additional mechanism contributing to the decline in cardiac function.
Conclusions: TLR4 was found to confer cardiac protection against HFD-induced changes, while potentially compromising cardiac function in response to AAC. Due to the complex interplay of various pathways, cautious interpretation of research outcomes is necessary before attributing specific pathways to observed results.
Details
- Title: Subtitle
- TLR-4 Modulates Cardiac Response to Stress: Insights from High Fat Diet and Pressure Overload
- Creators
- Mohamad MokademMohammad JarrahLiping TianHussein HerzBenjamin LindenYi Chu
- Resource Type
- Abstract
- Publication Details
- Obesity (Silver Spring, Md.), Vol.31(S2), pp.108-108
- Publisher
- Blackwell Publishing Ltd
- ISSN
- 1930-7381
- eISSN
- 1930-739X
- Comment
- (2023), Poster Abstracts. Obesity (Silver Spring), 31: 53-289. https://doi.org/10.1002/oby.23939
- Language
- English
- Date published
- 11/01/2023
- Academic Unit
- Surgery; Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984628220502771
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