Abstract
The Effect Of Acute Antioxidant Supplementation On Vascular Dysfunction With Aging: 3198 Board #1 May 30, 9 00 AM - 11 00 AM
Medicine and science in sports and exercise, Vol.47(5S), p.581
05/2015
DOI: 10.1249/01.mss.0000479034.52193.6d
Abstract
INTRODUCTION: Elevated oxidative stress (OS) and decreased nitric oxide bioavailability is a hallmark of aging, leading to reduced vasodilatory capacity and endothelial dysfunction. Antioxidant supplementation has been shown to scavenge free radicals and improve endothelial function and could be a potential treatment to offset these negative vascular effects seen in aging individuals. We therefore investigated the impact of aging and antioxidant supplementation on flow mediated dilation (FMD).
PURPOSE: To determine if antioxidant supplementation can improve measures of vascular function in both young (YA) and older adults (OA).
METHODS: Measurements of endothelial function were obtained in 89 individuals (45 young [mean age = 27 years] and 44 old [mean age = 59 years]) following both acute antioxidant (Vitamin C, Vitamin E and alpha lipoic acid) and placebo supplementation in a double blind, randomized, crossover designed study. FMD was assessed using ultrasound (Aloka). FMD values were compared between age groups using a repeated measures ANOVA. When the interaction was significant, the responses were evaluated with paired samples t-tests within each group and independent t-tests between age groups.
RESULTS: OA had significantly lower FMD% compared to YA in the placebo condition (6.21±0.54 versus 9.02±0.58, p=0.001). YA improved FMD% with the antioxidant (9.02±0.58 to 9.96±0.55) although this did not reach statistical significance (p=0.079). OA significantly improved FMD% (6.21±0.54 to 7.86±0.46, p=0.005) with antioxidant supplementation, yet OA were still significantly lower in FMD% compared to YA (p=0.007).
CONCLUSIONS: YA have greater endothelial function compared to OA, which is potentially due to the elevated oxidative stress seen in aging individuals. However, despite improvements in endothelial function in OA following antioxidant supplementation, OA continued to exhibit significantly lower FMD% compared to YA, which suggests that the endothelial dysfunction seen in aging can be attributed to factors beyond oxidative stress.
Details
- Title: Subtitle
- The Effect Of Acute Antioxidant Supplementation On Vascular Dysfunction With Aging: 3198 Board #1 May 30, 9 00 AM - 11 00 AM
- Creators
- Rebecca M. Kappus - University of Illinois Urbana-ChampaignKanokwan Bunsawat - University of Illinois Urbana-ChampaignAlexander J. Rosenberg - University of Illinois Urbana-ChampaignTracy Baynard - University of Illinois Urbana-ChampaignJacob M. Haus - University of Illinois Urbana-ChampaignShane Phillips - University of Illinois Urbana-ChampaignMichael D. Brown - University of Illinois Urbana-ChampaignBo Fernhall - University of Illinois Urbana-Champaign
- Resource Type
- Abstract
- Publication Details
- Medicine and science in sports and exercise, Vol.47(5S), p.581
- DOI
- 10.1249/01.mss.0000479034.52193.6d
- ISSN
- 0195-9131
- eISSN
- 1530-0315
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Language
- English
- Date published
- 05/2015
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984958627002771
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