Abstract
The Impact of Chronic Antioxidant Administration on Sympathetic Nervous System Activity and Vascular Function in Heart Failure Patients with a Reduced Ejection Fraction
The FASEB journal, Vol.33(S1), pp.564.4-564.4
04/2019
DOI: 10.1096/fasebj.2019.33.1_supplement.564.4
Abstract
Abstract only
Background
Heart failure with reduced ejection fraction (HFrEF) is characterized by sympathetic nervous system (SNS) overactivation and vascular dysfunction, two important predictors of mortality and morbidity in this patient group. Importantly, oxidative stress, defined as an excess production of free radicals relative to antioxidant defenses, is prevalent in patients suffering from HFrEF. This pro-oxidant state is associated with attenuated nitric oxide bioavailability, which may contribute to increased SNS activity and vascular dysfunction. While chronic oral antioxidant (AOx) administration has been documented to mitigate oxidative stress in other populations, the efficacy of this approach to improve autonomic and vascular function in patients with HFrEF has not been evaluated. Thus, this study sought to determine the effect of chronic (30-day) over-the-counter oral AOx administration on SNS activity and vascular function in patients with HFrEF.
Methods
Five HFrEF patients (71 ± 3 yrs; 28.5 ± 1.5 kg/m2) were studied before and after 30 days of oral AOx administration (Vitamin C, 1000 mg; Vitamin E, 600 IU; α-lipoic acid, 600 mg; QD). Resting muscle sympathetic nerve activity (MSNA) was assessed for the determination of SNS activity, and vascular function was evaluated by brachial artery flow-mediated dilation (FMD) testing. Venous blood samples were also collected for the direct determination of plasma free radical concentration (electron paramagnetic resonance spectroscopy, EPR).
Results
Chronic antioxidant administration reduced MSNA burst frequency (pre: 44 ± 3 bursts/min; post: 38 ± 2 bursts/min, p<0.05). FMD appeared to improve following AOx administration (pre: 2.7 ± 0.7%; post: 4.0 ± 1.0%), but this change did not reach statistical significance (p=0.18). A tendency for a reduction in plasma free radical concentration following AOx administration (pre: 3.2 ± 1.6 AU; post: 0.7 ± 0.1, p=0.11) was also observed.
Conclusion
Chronic antioxidant administration significantly reduced SNS activity and tended to improve vascular function, supporting the efficacy of this simple therapeutic approach to improve autonomic and vascular function in patients with HFrEF.
Details
- Title: Subtitle
- The Impact of Chronic Antioxidant Administration on Sympathetic Nervous System Activity and Vascular Function in Heart Failure Patients with a Reduced Ejection Fraction
- Creators
- Kanokwan Bunsawat - University of UtahStephen M Ratchford - University of UtahJeremy K Theisen - University of UtahSoung‐Hun Park - University of UtahJosef Stehlik - University of UtahOmar Wever-Pinzon - University of UtahStavros Drakos - University of UtahRussell S Richardson - University of UtahD. Walter Wray - University of Utah
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.33(S1), pp.564.4-564.4
- DOI
- 10.1096/fasebj.2019.33.1_supplement.564.4
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984958640002771
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