Abstract
The Lethal Crossroad: How Chronic Kidney Disease Fuels Heart Failure Mortality Across Generations - A Cdc Wonder Study (1999-2020)
Journal of cardiac failure, Vol.32(1), pp.240-241
01/2026
DOI: 10.1016/j.cardfail.2025.11.169
Abstract
Introduction
Chronic kidney disease (CKD) and heart failure (HF) are closely linked, with CKD worsening cardiovascular outcomes and increasing mortality risk. This study analyzes CDC WONDER data (1999-2020) to examine trends in HF mortality among CKD patients, highlighting age-related disparities and patterns that can inform public health strategies.
Methods
Using CDC WONDER data, we calculated AAMR per 100,000 for individuals aged 45-84 and 85+ who died from heart failure (HF) with chronic kidney disease (CKD). MCD analysis included HF (I50.0, I50.1, I50.9) and CKD (N18.0-N18.9). Joinpoint regression estimated APC and AAPC from 1999 to 2020.
Results
From 1999 to 2020, the AAMR for heart failure with CKD increased from 12.35 to 16.29 in 2005, then declined to its lowest in 2010 (13.15) before rising sharply to 25.67 in 2020 (AAPC: 2.9, 95% CI: 1.7 to 4.2). A total of 468,827 deaths were recorded, with males (24.3) having higher AAMRs than females (14.3). NH Black had the highest AAMR (26.77), followed by American Indian/Alaska Natives (21.6), NH White (17.57), Hispanic (15.08) and NH Asian/Pacific Islanders (11.73). Mortality was higher in non-metropolitan (21.37) vs. metropolitan areas (17.52) and varied regionally (West: 17.75; South: 17.56; Midwest: 21.16; Northeast: 16.39). California had the most deaths (53,627), with most nationwide (190,763) occurring in medical inpatients. Mortality peaked in the 85+ group (CMR: 169.2).
Conclusion
Heart failure mortality among CKD patients showed an overall increase from 1999 to 2020, with notable disparities by sex, race, and region. The highest mortality rates were observed in older adults, non-metropolitan areas, and NH Black individuals. The sharp rise in 2020 underscores the need for targeted interventions to improve outcomes in high-risk populations.
Details
- Title: Subtitle
- The Lethal Crossroad: How Chronic Kidney Disease Fuels Heart Failure Mortality Across Generations - A Cdc Wonder Study (1999-2020)
- Creators
- Muhammad Usman HaiderIshtiaq AhmadHaleema NawazHasan IlyasDaniah RizwanZaryab BachaHamna JawadIqra KhanMustafa AlsaadiFahad SaleemMaryam TariqMian Zahid Jan KakakhelVyom Patel
- Resource Type
- Abstract
- Publication Details
- Journal of cardiac failure, Vol.32(1), pp.240-241
- DOI
- 10.1016/j.cardfail.2025.11.169
- ISSN
- 1071-9164
- Publisher
- Elsevier
- Language
- English
- Date published
- 01/2026
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985129577702771
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