Abstract
The causal neuromodulation mechanisms of the left dorsolateral prefrontal cortex on the amygdala
Brain stimulation, Vol.16(1), p.391
01/01/2023
Abstract
The left dorsolateral prefrontal cortex (dlPFC) is a key region involved in emotion regulation and an effective target for repetitive transcranial magnetic stimulation (rTMS) treatment in depression. Evidence shows that the dlPFC connects with the amygdala, a region for emotional responses processing, during emotion regulation. Yet, our understanding of the causal regulatory role of the dlPFC on the amygdala is minimal. We performed 3 multimodal neuroimaging experiments. In Experiment 1 with concurrent TMS/fMRI, we stimulated 11 cortical regions in 82 healthy participants with single-pulse interleaved TMS in the scanner and simultaneously measured responses in the amygdala. We identified a main effect of TMS sites (F=2.74, p=0.002). The TMS to the left posterior dlPFC induced the strongest inhibitory effect in the amygdala. In Experiment 2 with concurrent TMS/fMRI, we stimulated anterior and posterior left dlPFC in 21 healthy controls (HC) and 20 patients with major depression disorder (MDD). We identified a significant interaction effect between TMS sites and groups (F=7.5, p=0.007). The inhibitory effect of the posterior dlPFC on the amygdala was perturbed in patients, indicating an altered posterior dlPFC-amygdala circuit in depression. Our Experiment 3 testified this assumption. First, the posterior dlPFC-amygala resting state functional connectivity (RSFC) differed between MDD and HC before treatment (left amygdala: t(44) = 4.91, p = 1.32e-5; right amygdala: t(44) = 3.07, p = 0.0036). Moreover, the treatment with active but not sham rTMS to the posterior dlPFC drove the posterior dlPFC-amygdala RSFC pattern in MDD similar to that seen in HC, (left amygdala: t(41) = 0.83, p = 0.41; right amygdala: t(41) = −0.23, p = 0.82). The findings together demonstrated the causal modulation of the dlPFC on the amygdala, and the rTMS may have improved the modulation in depression, providing important clinical implications for treatment optimization.
Details
- Title: Subtitle
- The causal neuromodulation mechanisms of the left dorsolateral prefrontal cortex on the amygdala
- Creators
- Jing Jiang - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Brain stimulation, Vol.16(1), p.391
- Publisher
- Elsevier
- ISSN
- 1935-861X
- eISSN
- 1876-4754
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Stead Family Department of Pediatrics; Psychiatry; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984368160202771
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