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The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer
Abstract   Open access  Peer reviewed

The combination of Paclitaxel and Gefitinib inhibits endometrial cancer cells by inducing mitotic catastrophe: proof of principle for dual therapy in endometrial cancer

Xiangbing Meng, Laura L Laidler, Lina Albitar, Anna M Holmes, Donghai Dai, Thomas E Buekers, David P Bender and Kimberly K Leslie
Proceedings in obstetrics and gynecology, Vol.2(1), pp.1-2
06/27/2011
DOI: 10.17077/2154-4751.1099
url
https://doi.org/10.17077/2154-4751.1099View
Published (Version of record) Open Access

Abstract

Serous uterine endometrial cancer is a lethal disease for which new therapeutic regimens are urgently needed. Combinations of chemotherapeutic agents and small molecule growth factor inhibitors have demonstrated activity in cancers from other sites. Our objective was to determine whether such a combination using Paclitaxel and Gefitinib could be active in serous endometrial cancer cells.

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