Abstract
The effects of 4 mA cerebellar transcranial direct current stimulation on gait and cerebral glucose uptake in people with multiple sclerosis
Brain stimulation, Vol.16(1), pp.359-360
01/01/2023
DOI: 10.1016/j.brs.2023.01.699
Abstract
Many people with multiple sclerosis (PwMS) use adaptive gait strategies which may increase theenergy demands during walking and increaseperformance fatigability. Gait training may improve mobility deficits and may be further amplified withtranscranial direct current stimulation (tDCS). Six PwMS (3 females, age range: 29 - 68) underwent nine sessions of 20 minutes of either 4 mA (N = 4) or Sham (N = 2) cerebellar tDCS before gait training. Gait was assessed (TUG, 25FWT, FGA, and 6MWT) pre- and post-intervention, and after 2- and 4-weeks. Additionally, the 4 mA group underwent positron emission tomography with [18F]fluorodeoxyglucose to evaluate cerebral glucose metabolism during treadmill walking. The tDCS group significantly improved post-intervention on the 6MWT (502.77 ± 27.14 vs. 558.53 ± 24.84, p = 0.01), with a trend towards significance on the TUG (10.28 ± 4.00 vs. 8.33 ± 5.01, p = 0.09). Additionally, improvements were shown on the 6MWT (2-week = 596.18 ± 66.06, p = 0.05), TUG (2-week = 7.66 ± 3.96, p< 0.01), and FGA (20.75 ± 12.01 vs. 23.00 ± 12.08, p = 0.02) 2-weeks post-intervention. There were no improvements in the Sham group (all p ≥ 0.36).Moreover, glucose metabolism (SUV in g/mL) during walking significantly decreased in movement-relatedbrain regions, including the left (7.91 ± 1.71 vs. 7.41 ± 1.67, p = 0.03) and right cerebellum (7.95 ± 1.75 vs. 7.42 ± 1.67, p = 0.04), left (9.53 ± 2.28 vs. 9.02 ± 2.06, p = 0.05) and right (9.73 ± 2.11 vs. 9.18 ± 1.96, p = 0.02) primary motor cortex, and right substantia nigra (7.53 ± 1.51 vs. 6.96 ± 1.51; p = 0.04) in the tDCS group. These results indicate that tDCS might amplify the effects of gait training, lowering the cerebral energy demands during walking.
Details
- Title: Subtitle
- The effects of 4 mA cerebellar transcranial direct current stimulation on gait and cerebral glucose uptake in people with multiple sclerosis
- Creators
- Alexandra C. Fietsam - University of IowaJustin R. Deters - University of IowaLaura L Boles Ponto - University of IowaThorsten Rudroff - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Brain stimulation, Vol.16(1), pp.359-360
- DOI
- 10.1016/j.brs.2023.01.699
- ISSN
- 1935-861X
- eISSN
- 1876-4754
- Publisher
- Elsevier
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Neurology; Radiology; Health, Sport, and Human Physiology
- Record Identifier
- 9984368052202771
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