Abstract
The role of serotonergic system in exercise‐facilitated passive avoidance task in rats
The FASEB journal, Vol.21(5)
04/2007
DOI: 10.1096/fasebj.21.5.A462-b
Abstract
It is known that amygdala and serotonin (5-HT) system play crucial roles in regulating fear memory. Whether exercise can facilitate fear memory via serotonin system is still unknown. Therefore, we examined levels of 5-HT and its metabolite (5-HIAA), the protein expression of serotonin receptors (5-HT1A, 5-HT2A) and 5-HT transporter in related brain regions (amygdala, hippocampus and prefrontal cortex) after 4-wk treadmill running in male Sprague-Dawley rats. Our results demonstrated that 1) treadmill exercise enhanced passive avoidance learning performance 24h after passive avoidance training; (2) exercise decreased protein expression of 5-HT1A and 5-HT2A in the amygdala, but not in the prefrontal cortex and hippocampus. In contrast, the expression of 5-HT transporter remained unaltered after exercise; (3) treadmill exercise decreased 5-HT levels, measured by HPLC, in the hippocampus; (4) pretreatment of the selective 5-HT1A agonist (8-OH-DPAT) impaired passive avoidance performance and completely abolished exercise-enhanced fear memory. Our results suggest that down-regulation of 5-HT1A receptor may be involved in exercise-enhanced fear memory.
Details
- Title: Subtitle
- The role of serotonergic system in exercise‐facilitated passive avoidance task in rats
- Creators
- Hsiun‐ing Chen - Department of PhysiologyNational Cheng Kung UniversityNo.1, Ta‐Hsiue Rd.Tainan701TaiwanLi‐Chun Lin - Department of PhysiologyNational Cheng Kung UniversityNo.1, Ta‐Hsiue Rd.Tainan701TaiwanChauying J Jen - Department of PhysiologyNational Cheng Kung UniversityNo.1, Ta‐Hsiue Rd.Tainan701Taiwan
- Resource Type
- Abstract
- Publication Details
- The FASEB journal, Vol.21(5)
- DOI
- 10.1096/fasebj.21.5.A462-b
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Language
- English
- Date published
- 04/2007
- Academic Unit
- Neuroscience and Pharmacology; Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984184142902771
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