Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis from 10 Prospective Cohort Studies in the Fatty Acids and Outcome Research Consortium (FORCE) (OR33-02-19)

Heidi Lai; Fumiaki Imamura; Andres Ardisson Korat; Rachel Murphy; Nathan Tintle; Julie Bassett; Jiaying Chen; Janine Kröger; Nita Forouhi; Matthias Schulze; William Harris; Vasan Ramachandran; Frank Hu; Graham Giles; Luc Djousse; Ingeborg Brouwer; Jason Wu; Matti Marklund; Renata Micha; Rozenn Lemaitre; Barbara McKnight; David Siscovick; Aladdin Shadyab; JoAnn Manson; Barbara Howard; Jennifer Robinson; Robert Wallace; Dariush Mozaffarian

doi:10.1093/cdn/nzz039.OR33-02-19

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Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis from 10 Prospective Cohort Studies in the Fatty Acids and Outcome Research Consortium (FORCE) (OR33-02-19)

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Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis from 10 Prospective Cohort Studies in the Fatty Acids and Outcome Research Consortium (FORCE) (OR33-02-19)

Heidi Lai, Fumiaki Imamura, Andres Ardisson Korat, Rachel Murphy, Nathan Tintle, Julie Bassett, Jiaying Chen, Janine Kröger, Nita Forouhi, Matthias Schulze, …

Current developments in nutrition, Vol.3(Supplement_1)

06/01/2019

DOI: 10.1093/cdn/nzz039.OR33-02-19

PMCID: PMC6577423

PMID: 31225136

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Abstract

Abstract Objectives To assess prospective association between circulating biomarkers of individual trans fatty acids (TFAs) and incident type 2 diabetes (T2D) in diverse populations. Methods A harmonized analysis of individual level data was conducted for TFA biomarkers and incident T2D by pooling ten prospective cohort or nested-case-control studies from five countries (Australia, Germany, Iceland, UK, and USA). Fatty acids (FAs) were measured in plasma phospholipid, red blood cell membrane phospholipid, or total plasma collected between 1990–2008 from 22,711 participants aged ≥18 years without prevalent diabetes. Evaluated TFAs included trans-16:1n-9, sum of trans-18:1 isomers (trans-18:1n6 to trans-18:1n12), sum of trans-18:2 isomers (cis/trans-18:2, trans/cis-18:2, trans/trans-18:2), and individual trans-18:2 isomers. The multivariable-adjusted relative risk or odds ratio was estimated in each cohort by lipid compartments using a pre-specified protocol for definitions of exposures, covariates, and outcomes for statistical analysis. Association estimates were pooled using fixed-effects inverse-variance weighted meta-analysis. Results During an average maximum of 14 years of follow-up, 2244 cases of incident T2D were identified. Median levels of TFAs across cohorts were 0.05–0.18% total FAs for trans-16:1n-9, 0.09–2.05% for total trans-18:1, 0.10–0.73% for total trans-18:2, and 0.01–0.36% for individual trans-18:2 isomers. In overall pooled analysis, TFAs evaluated per inter-quintile range were not significantly associated with risk of T2D (Figure 1). Findings were consistent when TFAs were assessed categorically in study specific-quintiles, and when associations were pooled within lipid compartment (i.e., phospholipids vs. total plasma). Conclusions Overall, biomarker levels of TFAs were not significantly associated with risk of incident T2D in this international pooling project. Findings may be due to mixed TFA sources (industrial vs. ruminant), a general decline in TFA exposure during this period, or no effect of circulating TFA on diabetes. Associations of TFA biomarkers with T2D at higher exposures should be investigated. Funding Sources See Table 1. Supporting Tables, Images and/or Graphs

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Title: Subtitle: Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis from 10 Prospective Cohort Studies in the Fatty Acids and Outcome Research Consortium (FORCE) (OR33-02-19)
Creators: Heidi Lai - Tufts University
Fumiaki Imamura - University of Cambridge
Andres Ardisson Korat - Harvard University
Rachel Murphy - University of British Columbia
Nathan Tintle - Dordt University
Julie Bassett - Cancer Council Victoria
Jiaying Chen - Brigham and Women's Hospital
Janine Kröger - German Institute of Human Nutrition
Nita Forouhi - University of Cambridge
Matthias Schulze - German Institute of Human Nutrition
William Harris
Vasan Ramachandran - Boston University
Frank Hu - Harvard University
Graham Giles - Cancer Council Victoria
Luc Djousse - Brigham and Women's Hospital
Ingeborg Brouwer - Vrije Universiteit Amsterdam
Jason Wu - The George Institute for Global Health, Faculty of Medicine, UNSW Sydney
Matti Marklund - The George Institute for Global Health
Renata Micha - Tufts University
Rozenn Lemaitre - University of Washington
Barbara McKnight - University of Washington
David Siscovick - New York Academy of Medicine
Aladdin Shadyab - University of California
JoAnn Manson - Brigham and Women's Hospital
Barbara Howard - Georgetown University Medical Center
Jennifer Robinson - University of Iowa
Robert Wallace - University of Iowa
Dariush Mozaffarian - Tufts University
Resource Type: Abstract
Publication Details: Current developments in nutrition, Vol.3(Supplement_1)
DOI: 10.1093/cdn/nzz039.OR33-02-19
PMID: 31225136
PMCID: PMC6577423
NLM abbreviation: Curr Dev Nutr
ISSN: 2475-2991
eISSN: 2475-2991
Language: English
Date published: 06/01/2019
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984364551702771

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