Abstract
W147 - Neural and Behavioral Habituation to Sad Infant Stimuli in Mothers who Use Substances
Drug and alcohol dependence, Vol.260(Supplement), 110848
07/01/2024
DOI: 10.1016/j.drugalcdep.2023.110848
Abstract
Aim: Studies on mothers who use substances have reported neural and behavioral differences in processing infant stimuli as compared to mothers not using substances. This study investigates the temporal dynamics of infant stimuli processing to understand when substance-use-related differences may emerge.
Methods: Thirty-three mothers who used substances during the perinatal period and thirty mothers who did not underwent functional magnetic resonance imaging while hearing infant cries and viewing sad and happy infant faces of their own infant and unknown infants across six runs of trials. After scanning, mothers rated the emotional intensity of each stimulus across ten trials. Repeated-measures ANOVAs assessed between-group differences in neural activity and rating responses to the infant stimuli across the runs and trials, respectively.
Results: For neural activity, a significant interaction between run, infant stimulus, brain region, and substance use status was observed (F80,4080=1.31, p=0.035). Differences in neural responses to infant stimuli between the two groups of mothers occurred mostly on later runs (runs 4-6): mothers using substances had lower neural activation to sad infant cries and faces in numerous brain regions including the amygdala, caudate, and orbitofrontal cortex. For subjective ratings, there was a significant interaction between trial, infant stimulus, infant identity, and substance use status (F18,1008=1.68, p=0.037): mothers using substances had comparable ratings on the first two trials, and significantly lower ratings beginning on the third and sixth trial for infant cries and sad faces, respectively.
Conclusions: While early neural and behavioral responses to infant stimuli were comparable across mothers, evidence of habituation towards infant stimuli, specifically sad infant stimuli, was present in mothers who use substances. These data suggest differential effects of maternal substance use on processing infant stimuli over time, which may have important implications to understanding maternal substance use and parenting behavior.
Details
- Title: Subtitle
- W147 - Neural and Behavioral Habituation to Sad Infant Stimuli in Mothers who Use Substances
- Creators
- Li Yan McCurdy - Yale UniversitySarah Yip - Yale UniversityPatrick Worhunsky - Yale UniversitySohye Kim - University of Massachusetts Chan Medical SchoolLane Strathearn - University of IowaMarc Potenza - Yale UniversityLinda Mayes - Yale UniversityHelena Rutherford - Yale University
- Resource Type
- Abstract
- Publication Details
- Drug and alcohol dependence, Vol.260(Supplement), 110848
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.drugalcdep.2023.110848
- ISSN
- 0376-8716
- eISSN
- 1879-0046
- Grant note
- National Institutes of Health: P01DA022446, R01DA026437, K01DA039299, P50HD103556, R03DA045289, T32DA019426-18
This work was supported by grants from the National Institutes of Health P01DA022446, R01DA026437, K01DA039299, P50HD103556 and R03DA045289. LYM is supported by T32-funded postdoctoral training fellowship (T32DA019426-18).
- Language
- English
- Date published
- 07/01/2024
- Academic Unit
- Psychiatry; Neuroscience and Pharmacology; Iowa Neuroscience Institute; Stead Family Department of Pediatrics; Developmental and Behavioral Pediatrics
- Record Identifier
- 9984658353002771
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