Abstract
WE-DE-BRA-10: Development of a Novel Scanning Beam Low-Energy Intraoperative Radiation Therapy (SBIORT) System for Pancreatic Cancer
Medical physics (Lancaster), Vol.43(6), pp.3814-3814
06/2016
DOI: 10.1118/1.4957839
Abstract
Purpose:
Developing a compact collimator system and validating a 3D surface imaging module for a scanning beam low-energy x-ray radiation therapy (SBIORT) system that enables delivery of non-uniform radiation dose to targets with irregular shapes intraoperatively.
Methods:
SBIORT consists of a low energy x-ray source, a custom compact collimator module, a robotic arm, and a 3D surface imaging module. The 3D surface imaging system (structure sensor) is utilized for treatment planning and motion monitoring of the surgical cavity. SBIORT can deliver non-uniform dose distributions by dynamically moving the x-ray source assembly along optimal paths with various collimator apertures. The compact collimator utilizes a dynamic shutter mechanism to form a variable square aperture. The accuracy and reproducibility of the collimator were evaluated using a high accuracy encoder and a high resolution camera platform. The dosimetrical characteristics of the collimator prototype were evaluated using EBT3 films with a Pantak Therapax unit. The accuracy and clinical feasibility of the 3D imaging system were evaluated using a phantom and a cadaver cavity.
Results:
The SBIORT collimator has a compact size: 66 mm diameter and 10 mm thickness with the maximum aperture of 20 mm. The mechanical experiment indicated the average accuracy of leaf position was 0.08 mm with a reproducibility of 0.25 mm at 95% confidence level. The dosimetry study indicated the collimator had a penumbra of 0.35 mm with a leaf transmission of 0.5%. 3D surface scans can be acquired in 5 seconds. The average difference between the acquired 3D surface and the ground truth is 1 mm with a standard deviation of 0.6 mm.
Conclusion:
This work demonstrates the feasibility of the compact collimator and 3D scanning system for the SBIORT. SBIORT is a way of delivering IORT with a compact system that requires minimum shielding of the procedure room.
This research is supported by the University of Iowa Internal Funding Initiatives
Details
- Title: Subtitle
- WE-DE-BRA-10: Development of a Novel Scanning Beam Low-Energy Intraoperative Radiation Therapy (SBIORT) System for Pancreatic Cancer
- Creators
- B Wears - University of Iowa Hospitals and Clinics, Iowa City, IAI Mohiuddin - University of Iowa Hospitals and Clinics, Iowa City, IAR Flynn - University of Iowa Hospitals and Clinics, Iowa City, IAT Waldron - University of Iowa Hospitals and Clinics, Iowa City, IAY Kim - University of Iowa Hospitals and Clinics, Iowa City, IAB Allen - University of Iowa Hospitals and Clinics, Iowa City, IAJ Xia - University of Iowa Hospitals and Clinics, Iowa City, IA
- Resource Type
- Abstract
- Publication Details
- Medical physics (Lancaster), Vol.43(6), pp.3814-3814
- DOI
- 10.1118/1.4957839
- ISSN
- 0094-2405
- eISSN
- 2473-4209
- Number of pages
- 1
- Grant note
- This research is supported by the University of Iowa Internal Funding Initiatives
- Date published
- 06/2016
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047609202771
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