Abstract
Whole spinal cord lesion detection with 1.5T and 3T MRI and clinical correlation in patients with multiple sclerosis
Multiple sclerosis, Vol.14(1_suppl), pp.S221-S221
09/01/2008
Abstract
Background: There is growing interest in using higher field MRI for assessing brain pathology in MS while few studies have examined its role in assessing spinal cord damage. Objective: Assess the relationship between spinal cord T2 lesions and clinical status in multiple sclerosis (MS) using both 1.5 and 3T MRI. Methods: Whole spine T2-weighted fast spin-echo MRI was performed at 1.5T and 3T in 32 MS patients [1 clinically isolated; 26 relapsing-remitting, 5 primary or secondary progressive; Expanded Disability Status Scale (EDSS) score (mean+SD) 2+/-1.9 (range 0-6.5), disease duration 8.18+7.4 (range 0.2-39) years]. Protocols were optimized and matched on voxel size. T2 hyperintense lesions were quantified using a semi-automated edge finding tool with scans randomized anonymously and intermixed with normal subjects. Results: At 1.5T, moderate correlations were found between whole spinal cord lesion number (Spearman rs = 0.46, p=0.01) or volume (rs = .36, p=0.04) and EDSS score. However, 3T lesion-EDSS correlations were weak (lesion number rs = 0.06, p=0.76; lesion volume rs = 0.13, p=0.46). In contrast, correlation between lesion volume and timed 25-foot walk were similar at 1.5T (Pearson r=0.38, p=0.04) and 3T (r=0.45, p=0.01). A higher whole cord lesion volume was present in progressive vs. relapsing patients at 1.5T (520+514 vs. 180+290 mm3, p=0.03), which showed a non-significant trend at 3T (485+495 vs. 139+157 mm3, p=0.09). Whole cord lesion number and volume did not differ between MRI platforms in the MS group (p>0.05). No lesions were found in normal controls. Conclusions: This study shows significant relationships between whole spinal cord T2 hyperintense lesion load and clinical status in patients with MS. The 1.5T and 3T MRI scanning protocols yielded relatively similar results for many but not all comparisons.
Details
- Title: Subtitle
- Whole spinal cord lesion detection with 1.5T and 3T MRI and clinical correlation in patients with multiple sclerosis
- Creators
- J StankiewiczM NeemaD AlsopB HealyA AroraG BuckleT ChitnisC GuttmannD HackneyR Bakshi
- Resource Type
- Abstract
- Publication Details
- Multiple sclerosis, Vol.14(1_suppl), pp.S221-S221
- ISSN
- 1352-4585
- eISSN
- 1477-0970
- Comment
- Poster Presentations. Multiple Sclerosis Journal. 2008;14(1_suppl):29-293. doi:10.1177/1352458508096399
- Language
- English
- Date published
- 09/01/2008
- Academic Unit
- Psychiatry
- Record Identifier
- 9984631942602771
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