Abstract
Zmiz1 is overexpressed in epithelial ovarian cancer and associated with p53 gene mutations
Gynecologic Oncology, Vol.123(2), pp.446-447
11/2011
DOI: 10.1016/j.ygyno.2011.07.084
Abstract
Objective: A recent transposon mutagenesis screen has identified the Zmiz1 gene as a new potential oncogene in carcinomas of the skin. It is well known that mutations of the p53 tumor suppressor gene are the most common genetic alterations in epithelial ovarian cancer. Previous studies have shown that Zmiz1 appears to transcriptionally regulate the p53 gene. There are no studies that evaluate Zmiz1expression and alterations in the p53 gene in gynecologic malignancies, specifically epithelial ovarian cancer. We hypothesize Zmiz1 expression is elevated in epithelial ovarian tumors and there is an interaction between Zmiz1 and the p53 tumor suppressor gene in ovarian tumors.
Details
- Title: Subtitle
- Zmiz1 is overexpressed in epithelial ovarian cancer and associated with p53 gene mutations
- Creators
- N NadkarniL Rogers - University of Iowa, Holden Comprehensive Cancer CenterM Samuelson - University of Iowa, PathologyT Neff - University of Iowa, Internal MedicineD Bender - University of Iowa, Obstetrics and GynecologyA Ahmed - University of Iowa, Pharmaceutical Sciences and Experimental TherapeuticsK De Geest - Oregon Health & Science UniversityA ButtonA Dupuy - University of Iowa, Anatomy and Cell BiologyM Goodheart - University of Iowa, Obstetrics and Gynecology
- Resource Type
- Abstract
- Publication Details
- Gynecologic Oncology, Vol.123(2), pp.446-447
- DOI
- 10.1016/j.ygyno.2011.07.084
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Language
- English
- Date published
- 11/2011
- Academic Unit
- Internal Medicine; Holden Comprehensive Cancer Center; Obstetrics and Gynecology; Pathology; Anatomy and Cell Biology
- Record Identifier
- 9983557640602771
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