Book
Reshaping of an anti-varicella zoster virus antibody
01/01/1994
Abstract
VZV is the causative agent of chickenpox and shingles. The murine monoclonal antibody 206, raised against viral coat glycoprotein gpIII, neutralizes VZV in the absence of human complement, blocks viral entry into cells and inhibits cell-to-cell spread of the virus in cultured cells. We have reconstructed Mab206 using CDR-grafting techniques. This reshaped antibody retained binding affinity for VZV gpIII and also cross-reacted with all clinical isolates of VZV tested.
Details
- Title: Subtitle
- Reshaping of an anti-varicella zoster virus antibody
- Creators
- M MossC GroseF CarrM FitzekA TurnerP WhiteW Harris
- Resource Type
- Book
- ISBN
- 9780852953358; 0852953356
- ISSN
- 0307-0492
- Language
- English
- Date published
- 01/01/1994
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984354146902771
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