10.18 - Sulfotransferases

M.W. Duffel

doi:10.1016/B978-0-12-801238-3.95623-X

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Book chapter

10.18 - Sulfotransferases

M.W. Duffel

Comprehensive Toxicology, pp.407-428

Elsevier Ltd, Third Edition

2018

DOI: 10.1016/B978-0-12-801238-3.95623-X

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Abstract

Sulfotransferases catalyze the formation of sulfuric acid esters, most often referred to as sulfates, from a wide range of xenobiotics and their metabolites, as well as various endogenous neurotransmitters, hormones, bile acids, carbohydrates, and proteins. This article is focused on the cytosolic sulfotransferases, a superfamily of enzymes that, depending on the specific substrates and products of the sulfation reaction, are responsible for either detoxication or metabolic activation of a wide range of drugs, toxins, carcinogens, environmental chemicals, and other xenobiotics. An overview of current aspects of the nomenclature, gene organization, regulation of expression, enzyme structures and catalytic mechanisms, specificities for substrates and inhibitors, and roles in toxicology is provided for these cytosolic sulfotransferases.

Allylic alcohols

Benzylic alcohols

Dehydroepiandrosterone

Detoxication

Hydroxysteroid

Inhibition

Metabolic activation

N-hydroxy arylamines and nuclear receptors

PAPS

Phenols

Sulfate

Sulfation

Sulfotransferase

SULT

ISRP Project 3 2015-2020

Details

Title: Subtitle: 10.18 - Sulfotransferases
Creators: M.W. Duffel - University of Iowa, Iowa City, IA, United States
Resource Type: Book chapter
Publication Details: Comprehensive Toxicology, pp.407-428
Edition: Third Edition
DOI: 10.1016/B978-0-12-801238-3.95623-X
Publisher: Elsevier Ltd
Language: English
Date published: 2018
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics; Iowa Superfund Research Program; Medicinal and Natural Products Chemistry
Record Identifier: 9984285538202771

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