Book chapter
159 - Metabolic Studies Using PET in Stroke Investigation
Primer on Cerebrovascular Diseases, pp.644-650
Academic Press
1997
DOI: 10.1016/B978-012743170-3.50160-6
Abstract
This chapter reviews metabolic studies using positron emission tomography (PET) in stroke investigation. PET uniquely provides accurate, quantitative, and repeatable in vivo measurements of regional cerebral hemodynamics and metabolism in humans. PET has provided us with unique information regarding the pathophysiologic mechanisms involved in the evolution of acute ischemic stroke. PET information has both confirmed and complemented data from experimental stroke models using more invasive methods of measurements. PET studies performed in humans in the setting of acute ischemia have demonstrated regions of both decreased and increased blood flow. The regions of decreased regional cerebral blood flow (rCBF) are because of persisting ischemia or postischemic hypoperfusion. Regions with increased rCBF are attributed to early postischemic hyperperfusion, caused by either clotlysis or collateral reperfusion. PET will continue to play a significant role in clinical research into the pathophysiology and treatment of human cerebrovascular disease.
Details
- Title: Subtitle
- 159 - Metabolic Studies Using PET in Stroke Investigation
- Creators
- Colin P Derdeyn - Mallinckrodt Institute of Radiology, Washington University of School of Medicine, St. Louis, Missouri 63130, USAWilliam J Powers - Division of Radiological Sciences, Mallinckrodt Institute of Radiology, and Department of Neurology and Neurological Surgery (Neurology), Washington University School of Medicine and the Lillian Strauss Institute of the Jewish Hospital of St. Louis, St. Louis, Missouri 63130, USA
- Resource Type
- Book chapter
- Publication Details
- Primer on Cerebrovascular Diseases, pp.644-650
- DOI
- 10.1016/B978-012743170-3.50160-6
- Publisher
- Academic Press
- Language
- English
- Date published
- 1997
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984071721902771
Metrics
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