Book chapter
21 - Leptin Signaling in the Central Nervous System
Primer on the Autonomic Nervous System, pp.86,VI-89,VI
Elsevier Inc, Second Edition
2004
DOI: 10.1016/B978-012589762-4/50022-0
Abstract
The leptin receptor is a single transmembrane protein belonging to the cytokine receptor superfamily; it signals through the Janus kinase/ signal transducer and activator of transcription (JAK/STAT) pathway. Phosphorylated STAT proteins translocate to the nucleus and stimulate transcription of the target gene. The leptin receptor has divergent signaling capacities as its activation modulates the activity of different intracellular enzymes, including mitogen-activated protein kinase, phosphoinositol 3 kinase, type 3 phosphodiesterase, insulin receptor substrate protein, and protein kinase C. These different intracellular pathways might mediate some central neural effects of leptin. For example, the leptin-induced hyperpolarization of subsets of hypothalamic neurons that occurs within minutes of application is mediated by phosphoinositol 3 kinase.
Details
- Title: Subtitle
- 21 - Leptin Signaling in the Central Nervous System
- Creators
- Kamal RahmouniWilliam G HaynesAllyn L Mark
- Resource Type
- Book chapter
- Publication Details
- Primer on the Autonomic Nervous System, pp.86,VI-89,VI
- Edition
- Second Edition
- DOI
- 10.1016/B978-012589762-4/50022-0
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2004
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984070540902771
Metrics
24 Record Views