Book chapter
2.16 - Genetics of Mechanoreceptor Evolution and Development
The Senses, pp.277-301
Elsevier Inc, Second Edition
2020
DOI: 10.1016/B978-0-12-809324-5.24192-8
Abstract
Mechanosensation at its core requires opening transmembrane proteins through mechanical forces. Such forces can act within the lipid bilayer (force-by-lipid) or though intracellular and/or extracellular connections (force-by-tether). Building on the assumption that specialized, tethered mechanotransduction channels evolved from lipid embedded channels, the current literature is reviewed. Data reveal multiple families of mechanotransduction channels that evolved in single celled organisms but were also sensitive to other sensory stimulations. Several of these channels were eventualy recruited to become mechnosenstive channels in metazoans. Why and how the TMC channels were selected for and become part of or the actual mechanotransduction channel of vertebrate hair cells is discussed.
Details
- Title: Subtitle
- 2.16 - Genetics of Mechanoreceptor Evolution and Development
- Creators
- Bernd Fritzsch - Department of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV, United StatesAlbert Erives - Department of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV, United StatesDaniel F Eberl - Department of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV, United StatesEbenezer N Yamoah - Department of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV, United States
- Resource Type
- Book chapter
- Publication Details
- The Senses, pp.277-301
- Edition
- Second Edition
- DOI
- 10.1016/B978-0-12-809324-5.24192-8
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2020
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984071684402771
Metrics
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