Book chapter
[23] Regulation of cerebral circulation by nitric oxide
Methods in Neurosciences, pp.264-272
1996
DOI: 10.1016/S1043-9471(96)80026-7
Abstract
This chapter discusses the regulation of cerebral circulation by nitric oxide (NO). NO is a highly diffusible messenger molecule that plays an important role in a diverse group of biological systems. NO is produced from l-arginine by the NO synthase (NOS) family of enzymes. Three separate genes control the expression of endothelial, neuronal, and inducible (or immunologic) isoforms of NOS. NO plays an important role in the regulation of the cerebral circulation. All three genes for NOS can be expressed in the wall of cerebral vessels. Endothelial and neuronal NOSs are expressed constitutively in endothelium and in NOS-containing neurons in the adventitia, respectively. Inducible NOS (iNOS) can be expressed in cerebral endothelium and presumably in vascular muscle in response to stimuli, such as lipopolysaccharide and some cytokines. Emphasis is placed on functions of NO under physiological conditions and in situations when data are available on molecular biology of NO synthase in cerebral vessels.
Details
- Title: Subtitle
- [23] Regulation of cerebral circulation by nitric oxide
- Creators
- Frank M. Faraci
- Resource Type
- Book chapter
- Publication Details
- Methods in Neurosciences, pp.264-272
- DOI
- 10.1016/S1043-9471(96)80026-7
- ISSN
- 1043-9471
- Language
- English
- Date published
- 1996
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984303855002771
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