4.18 - Sulfotransferases

M.W. Duffel

doi:10.1016/B978-0-08-046884-6.00418-8

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Book chapter

4.18 - Sulfotransferases

M.W. Duffel

Comprehensive Toxicology, pp.367-384

Elsevier Ltd, Second Edition

2010

DOI: 10.1016/B978-0-08-046884-6.00418-8

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Abstract

Sulfotransferases catalyze the formation of sulfuric acid esters, most often referred to as sulfates, from a wide range of xenobiotics and their metabolites, as well as various endogenous neurotransmitters, hormones, bile acids, carbohydrates, and proteins. This chapter is focused on the cytosolic sulfotransferases, a superfamily of enzymes that, depending on the specific substrates and products of the sulfation reaction, are responsible for either detoxication or metabolic activation of a wide range of drugs, toxins, carcinogens, environmental chemicals, and other xenobiotics. An overview of current aspects of the nomenclature, gene organization, regulation of expression, enzyme structures and catalytic mechanisms, specificities for substrates and inhibitors, and roles in toxicology is provided for these cytosolic sulfotransferases.

AhR

allylic alcohols

benzylic alcohols

dehydroepiandrosterone

detoxication

glutathione

hydroxysteroid

inhibition

metabolic activation

N-hydroxy arylamines

nuclear receptors

PAPS

phenols

stereospecificity

sulfate

sulfation

sulfotransferase

SULT

Details

Title: Subtitle: 4.18 - Sulfotransferases
Creators: M.W. Duffel - University of Iowa
Resource Type: Book chapter
Publication Details: Comprehensive Toxicology, pp.367-384
Edition: Second Edition
DOI: 10.1016/B978-0-08-046884-6.00418-8
Publisher: Elsevier Ltd
Language: English
Date published: 2010
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics; Iowa Superfund Research Program; Medicinal and Natural Products Chemistry
Record Identifier: 9984285537802771

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