Book chapter
551DNA Immunomodulation of Asthma
Inflammatory Mechanisms in Allergic Diseases, pp.551-564
CRC Press, 1
2002
DOI: 10.1201/9780429134432-30
Abstract
Few developments in the history of immunology rival Jenner's use of cowpox to confer immunity against smallpox (1). One can safely state that Jenner's experiments were the forerunners of what is now referred to as immunomodulation or, more generally, biological response modification. Many vaccines have been developed since, but most are centered around modifications of the same basic idea: administer an attenuated, killed, or related pathogen to a naïve population to induce protective immunity (2, 3). More recently, peptides (which bypass the antigen-presenting process) have been used as immunogens, with limited success. With the advent of molecular biology techniques, the potential for biological response modification has expanded to encompass selective targeting of certain genes. Recent technical advances have conferred the capacity of regulating the "dose" of a given gene from total inactivation (knockout) to expression in every cell (transgenic). Between these two ends of the spectrum, one can determine where, or when, a certain gene can be expressed by controlling the promotor region or by using an antibiotic selection marker, respectively (4, 5). Regulation of the gene dose is readily accomplished in mice by manipulating the embryonic stem cell; this is clearly not feasible in humans.
Details
- Title: Subtitle
- 551DNA Immunomodulation of Asthma
- Creators
- Joel N. Kline - University of IowaZuhair K. Ballas - University of Iowa
- Contributors
- Burton Zweiman (Editor)Lawrence B. Schwartz (Editor)
- Resource Type
- Book chapter
- Publication Details
- Inflammatory Mechanisms in Allergic Diseases, pp.551-564
- Edition
- 1
- Publisher
- CRC Press
- DOI
- 10.1201/9780429134432-30
- Alternative title
- DNA Immunomodulation of Asthma
- Language
- English
- Date published
- 2002
- Academic Unit
- Occupational and Environmental Health; Immunology; Internal Medicine; Pulmonary, Critical Care, and Occupational Medicine
- Record Identifier
- 9984361726502771
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